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For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
PHR1438
Simvastatin
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
Simvastatin
Select a Size
CZK 2,541.50
CZK 2,541.50
List PriceCZK 2,990.00Save 15%About This Item
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Product Name
Simvastatin, Pharmaceutical Secondary Standard; Certified Reference Material
InChI
1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
SMILES string
[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)C(C)(C)CC
InChI key
RYMZZMVNJRMUDD-HGQWONQESA-N
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. S0650000
traceable to USP 1612700
API family
simvastatin
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
127-132 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
-10 to -25°C
Quality Level
Gene Information
human ... HMGCR(3156)
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1 of 4
This Item | S0650000 | 1612700 | BP739 |
|---|---|---|---|
| application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical |
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - |
| format neat | format neat | format neat | format neat |
| Quality Level 300 | Quality Level - | Quality Level - | Quality Level - |
| grade certified reference material, pharmaceutical secondary standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard |
| storage temp. -10 to -25°C | storage temp. - | storage temp. - | storage temp. −20°C |
Analysis Note
Application
Biochem/physiol Actions
General description
Simvastatin is a hypolipidemic drug, which lowers plasma cholesterol by inhibiting 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase. It is widely used in the treatment of hypercholesterolemia.[4]
Other Notes
comparable product
related product
signalword
Warning
hcodes
Hazard Classifications
Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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How can I determine the shelf life / expiration / retest date of this product?
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Helpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
Helpful?
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What is Product PHR1438, Simvastatin, soluble in? And how to keep the stock solution?
1 answer-
This product can be prepared by dissolving 50 mg in 1 ml in ethanol plus 0.813 ml of 1N NaOH. Solutions are stable for at least 1 month at -20°C. Prior to use, adjust the pH to 7.2 by adding 1N HCl, dropwise. Neutralized solutions should be used immediately. Simvastatin is also soluble at >20 mg/mL in DMSO. Long term solution stability in DMSO has not been determined. See the links below for other Simvastatin products that provide additional helpful information in addition to use as an analytical standard.
567020
https://www.sigmaaldrich.com/product/mm/567020Helpful?
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