L1026

Lidocaine

Na+ channel blocker, solid

• Synonym(s): 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine
• Empirical Formula (Hill Notation): C₁₄H₂₂N₂O
• CAS Number: 137-58-6
• Molecular Weight: 234.34
• NACRES: NA.77
• PubChem Substance ID: 24896272
• UNSPSC Code: 12352200
• EC Number: 205-302-8
• MDL number: MFCD00026733

Properties

• Product Name: Lidocaine, analytical standard
• InChI key: NNJVILVZKWQKPM-UHFFFAOYSA-N
• InChI: 1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
• SMILES string: CCN(CC)CC(=O)Nc1c(C)cccc1C
• grade: analytical standard
• form: solid
• packaging: vial of 200 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• impurities: ≤0.5% Total Organic Impurities (Lidocaine related compound H ≤0.10%; ; ; 2,6-Dimethylaniline ≤0.01%; ; ; Any unspecified impurity ≤0.10%; ; ; Total impurities ≤0.5%)
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• Quality Level: 200
• Gene Information: human ... CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335) ; rat ... Scnn1a(25122)

Description

Application

Lidocaine has been used to examine its effects in inhibiting lymph flow and protection against envenomation.[1] It has also been used to assess its efficacy as an anti-tussive agent.[2]

Biochem/physiol Actions

Na⁺ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.

Na⁺ channel blocker; class IB antiarrhythmic.

General description

Lidocaine is an amide anesthetic,[3] which is used to treat ventricular arrhythmias.[4] It lowers cardiac automaticity and myocardial conduction.[3] Lidocaine inhibits the generation and conduction of nerve impulses.[5] It has an anticonvulsant effect.[6]

Packaging

Supplied in amber screw-cap vials

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves