PZ0012

Sunitinib malate

≥98% (HPLC), powder, receptor tyrosine kinase inhibitor

• Synonym(s): N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt, SU 011248, SU 11248, SU112248
• Empirical Formula (Hill Notation): C₂₂H₂₇FN₄O₂ · C₄H₆O₅
• CAS Number: 341031-54-7
• Molecular Weight: 532.56
• MDL number: MFCD08282795
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823681
• NACRES: NA.77

Properties

• Product Name: Sunitinib malate, ≥98% (HPLC)
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: >10 mg/mL
• storage temp.: room temp
• SMILES string: O[C@@H](CC(O)=O)C(O)=O.CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
• InChI: 1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1
• InChI key: LBWFXVZLPYTWQI-IPOVEDGCSA-N
• Gene Information: human ... CSF1R(1436), FLT1(2321), FLT3(2322), FLT4(2324), KDR(3791), KIT(3815), PDGFRA(5156), PDGFRB(5159), RET(5979)

Description

Application

Sunitinib malate has been used:

• to study its mechanism in the inhibition of MCF-7 cell migration and angiogenesis[1]
• as a reference molecule to compare its docking energies with other ligands/vascular endothelial growth factor receptor (VEGF) receptor blocker[2]
• used in proliferation assay[3]

Biochem/physiol Actions

Sunitinib has greater bioavailability and potency compared to other inhibitors. It prevents angiogenesis.[4]

Sunitinib malate is a receptor tyrosine kinase inhibitor, which targets VEGF-R1, VEGF-R2, VEGF-R3, PDGF-Rα, PDGF-Rβ, KIT, FLT3, CSF-1R, and RET. Sunitinib malate is an anticancer drug.

Features and Benefits

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Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H360,H372
• Precautionary Statements: P202 - P260 - P264 - P280 - P308 + P313 - P405
• Hazard Classifications: Repr. 1B - STOT RE 1 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable