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Merck

G2128

L-Glutamic acid hydrochloride

≥99% (HPLC), kainate, NMDA, and quisqualate agonist

Synonym(s):

(S)-2-Aminoglutaric acid, (S)-2-Aminopentanedioic acid ammonium salt, Glu HCl

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€38.40

500 G

€83.89

1 KG

€186.00

€38.40

Estimated to ship on22 December 2025Details

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About This Item

Empirical Formula (Hill Notation):
C5H9NO4 · HCl
CAS Number:
138-15-8
Molecular Weight:
183.59
NACRES:
NA.32
PubChem Substance ID:
24277982
UNSPSC Code:
12352106
EC Number:
205-315-9
MDL number:
MFCD00012619
Beilstein/REAXYS Number:
3565569

Key Documents

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Product Name

L-Glutamic acid hydrochloride, ≥99% (HPLC)

InChI key

RPAJSBKBKSSMLJ-DFWYDOINSA-N

InChI

1S/C5H9NO4.ClH/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H/t3-;/m0./s1

SMILES string

Cl.N[C@@H](CCC(O)=O)C(O)=O

assay

≥99% (HPLC)

Quality Level

300

Gene Information

human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)

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1 of 4

This Item
G1626G15018.14632
L-Glutamic acid hydrochloride ≥99% (HPLC)

Sigma-Aldrich

G2128

L-Glutamic acid hydrochloride

L-Glutamic acid monosodium salt hydrate ≥99% (HPLC), powder

Sigma-Aldrich

G1626

L-Glutamic acid monosodium salt hydrate

L-Glutamic acid potassium salt monohydrate ≥99% (HPLC), powder

Sigma-Aldrich

G1501

L-Glutamic acid potassium salt monohydrate

L-Glutamic acid hydrochloride for synthesis

Sigma-Aldrich

8.14632

L-Glutamic acid hydrochloride

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

200

Gene Information

human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)

Gene Information

human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)
mouse ... GRIK1(14805), GRIK2(14806), GRIK3(14807), GRIK4(110637), GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)
rat ... GRIK1(29559), GRIK2(54257), GRIK3(298521), GRIK4(24406), GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)

Gene Information

human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)
mouse ... GRIK1(14805), GRIK2(14806), GRIK3(14807), GRIK4(110637), GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)
rat ... GRIK1(29559), GRIK2(54257), GRIK3(298521), GRIK4(24406), GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)

Gene Information

-

Application

L-Glutamic acid hydrochloride has been used as a nutrient additive to study the effect of increased dissolved inorganic nitrogen (DIN) on the uptake of dissolved organic nitrogen (DON) and dissolved organic carbon (DOC), in a nitrogen-limited headwater forest stream.[1]

Biochem/physiol Actions

Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.
L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Huntington′s disease and Parkinson′s disease.[2] Glutamate is also responsible for the activation of long-term potentiation (LTP) and long-term depression (LTD). Induction of glutamate receptors plays a key role in the pathophysiology of migraine.[3]

General description

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors.[2]

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF3092V
WXBF0271V
WXBD6230V
WXBD6036V
WXBD4491V

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Coupled cycling of dissolved organic nitrogen and carbon in a forest stream.
Brookshire E N J et al
Ecology, 86(9), 2487-2496 (2005)
B K Day et al.
Journal of neurochemistry, 96(6), 1626-1635 (2006-01-31)
L-glutamate (Glu) is the predominant excitatory neurotransmitter in the mammalian central nervous system. It plays major roles in normal neurophysiology and many brain disorders by binding to membrane-bound Glu receptors. To overcome the spatial and temporal limitations encountered in previous
Martina Curto et al.
The journal of headache and pain, 17, 47-47 (2016-05-01)
Activation of glutamate (Glu) receptors plays a key role in the pathophysiology of migraine. Both NMDA and metabotropic Glu receptors are activated or inhibited by metabolites of the kynurenine pathway, such as kynureninic acid (KYNA), quinolinic acid (QUINA), and xanthurenic
Wei Lu et al.
Neuron, 78(3), 433-439 (2013-05-15)
The cell-autonomous role of synaptic transmission in the regulation of neuronal structural and electrical properties is unclear. We have now employed a genetic approach to eliminate glutamatergic synaptic transmission onto individual CA1 pyramidal neurons in a mosaic fashion in vivo. Surprisingly
A new beginning for a broken mind: balancing neuregulin 1 reverses synaptic dysfunction.
Oscar Marín et al.
Neuron, 78(4), 577-579 (2013-05-31)
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