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Merck

P7527

Prostaglandin E1

powder, γ-irradiated, BioXtra, suitable for cell culture

Synonym(s):

(11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE1

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1 MG

€443.70

10 MG

€630.00

€443.70

List Price€522.00Save 15%

Estimated to ship on15 December 2025Details

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About This Item

Empirical Formula (Hill Notation):
C20H34O5
CAS Number:
745-65-3
Molecular Weight:
354.48
Beilstein:
5294062
EC Number:
212-017-2
MDL number:
MFCD00077860
UNSPSC Code:
12352209
PubChem Substance ID:
24898855
NACRES:
NA.77
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥60% (HPLC)

Key Documents

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biological source

synthetic (organic)

Quality Level

200

sterility

γ-irradiated

product line

BioXtra

Assay

≥60% (HPLC)

form

powder

concentration

≥60% (HPLC)

technique(s)

cell culture | mammalian: suitable

solubility

ethanol: 1 mg/mL

storage temp.

−20°C

SMILES string

O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1

InChI

1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1

InChI key

GMVPRGQOIOIIMI-DWKJAMRDSA-N

Gene Information

human ... PTGER1(5731), PTGER2(5732), PTGIR(5739)
mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)

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1 of 4

This Item
P8908P5515538903
Prostaglandin E1 powder, γ-irradiated, BioXtra, suitable for cell culture

Sigma-Aldrich

P7527

Prostaglandin E1

Prostaglandin E1 synthetic, powder, BioReagent, suitable for cell culture

Sigma-Aldrich

P8908

Prostaglandin E1

Prostaglandin E1 ≥98% (HPLC), synthetic

Sigma-Aldrich

P5515

Prostaglandin E1

Prostaglandin E1 Activates adenylate cyclase activity via a G-protein coupled receptor.

Millipore

538903

Prostaglandin E1

biological source

synthetic (organic)

biological source

synthetic

biological source

synthetic

biological source

-

assay

≥60% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

product line

BioXtra

product line

BioReagent

product line

-

product line

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

form

powder

form

powder

form

(powder to crystals)

form

solid

Application

For use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.
Prostaglandin E1 has been used in maintaining mice proximal tubule,[1] and NRK-52E, a rat renal epithelial cell line.[2]

Biochem/physiol Actions

Prostaglandins mediate vasodilation and vasoconstriction, the E series of prostaglandin is a highly effective vasodilator. It is known to efficiently cause erythema. Prostaglandin E1 is considered as a potent pyretic factor, and acts through cerebral ventricles.[3] Prostaglandin E1 is useful to prolong cardiovascular function in new born suffering from ductus-dependant congenital heart disease until surgery.[4]

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000443120
0000443120
0000448003
0000448003
0000314222

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Naturally produced crystals obtained from kidney stones are less injurious to renal tubular epithelial cells than synthetic crystals
Escobar C, et al.
BJU International, 100(4), 891-897 (2007)
Long-term prostaglandin E1 infusion for newborns with critical congenital heart disease
Aykanat A, et al.
Pediatric Cardiology, 37(1), 131-134 (2016)
Stephen A Davis et al.
Nature chemical biology, 11(7), 481-487 (2015-06-02)
Drugs that act more promiscuously provide fewer routes for the emergence of resistant mutants. This benefit, however, often comes at the cost of serious off-target and dose-limiting toxicities. The classic example is the antifungal amphotericin B (AmB), which has evaded
The Prostaglandins (2013)
Signe E Cremer et al.
PloS one, 14(11), e0224891-e0224891 (2019-11-14)
Domestic dogs share the same environment as humans, and they represent a valuable animal model to study naturally-occurring human disease. Platelet proteomics holds promise for the discovery of biomarkers that capture the contribution of platelets to the pathophysiology of many
View All Related Papers

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