P8908

Prostaglandin E₁

synthetic, powder, BioReagent, suitable for cell culture

• Synonym(s): (11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE₁
• Empirical Formula (Hill Notation): C₂₀H₃₄O₅
• CAS Number: 745-65-3
• Molecular Weight: 354.48
• UNSPSC Code: 12352209
• NACRES: NA.77
• PubChem Substance ID: 24898994
• EC Number: 212-017-2
• Beilstein/REAXYS Number: 5294062
• MDL number: MFCD00077860
• Biological source: synthetic
• Form: powder
• Assay: ≥98% (HPLC)

Properties

• Product Name: Prostaglandin E₁, synthetic, powder, BioReagent, suitable for cell culture
• form: powder
• InChI: 1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
• InChI key: GMVPRGQOIOIIMI-DWKJAMRDSA-N
• SMILES string: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1
• biological source: synthetic
• product line: BioReagent
• assay: ≥98% (HPLC)
• potency: 0.25-100 ng/mL
• technique(s): cell culture | mammalian: suitable
• solubility: acetone: 10 mg/mL, clear, colorless
• storage temp.: −20°C
• Quality Level: 200
• Gene Information: human ... PTGER1(5731), PTGER2(5732), PTGIR(5739) ; mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)

Description

Application

Prostaglandin E1 may be used in cell culture to protect human umbilical vein endothelial cells (HUVEC) from injury induced by hydrogen peroxide.

Biochem/physiol Actions

Prostaglandin E₁ (PGE1) aids in the relaxation of corporal cavernosal tissue.[1] It helps to preserve the patency of the ductus arteriosus.[2][3] It is used to treat erectile dysfunction (ED).[4]

General description

Prostaglandin E₁ (PGE1) is a vasodilator.[2]

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves