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T7513

Thrombin from bovine plasma

lyophilized powder, ≥2,000 NIH units/mg protein (E1%/280 = 19.5)

Synonym(s):

Factor IIa

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50 UNITS

1.150,00 kr.

100 UNITS

2.060,00 kr.

250 UNITS

2.480,00 kr.

500 UNITS

3.880,00 kr.

1.150,00 kr.

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About This Item

CAS Number:
9002-04-4
EC Number:
3.4.21.5 (BRENDA, IUBMB)
EC Number:
232-648-7
MDL number:
MFCD00166053
UNSPSC Code:
12352204
NACRES:
NA.54

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form

lyophilized powder

Quality Level

200

specific activity

≥2,000 NIH units/mg protein (E1%/280 = 19.5)

mol wt

heavy chain ~33 kDa
light chain ~5 kDa

UniProt accession no.

P00735

application(s)

diagnostic assay manufacturing

storage temp.

−20°C

Gene Information

cow ... F2(280685)

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1 of 4

This Item
T6634T4648T1063
Thrombin from bovine plasma lyophilized powder, ≥2,000 NIH units/mg protein (E1%/280 = 19.5)

Sigma-Aldrich

T7513

Thrombin from bovine plasma

Thrombin from bovine plasma lyophilized powder, 600-2,000 NIH units/mg protein (biuret)

Sigma-Aldrich

T6634

Thrombin from bovine plasma

Thrombin from bovine plasma lyophilized powder, 40-500 NIH units/mg protein (biuret)

Sigma-Aldrich

T4648

Thrombin from bovine plasma

Thrombin from human plasma lyophilized powder, ≥2800 NIH units/mg protein (E1%/280, 18.3)

Sigma-Aldrich

T1063

Thrombin from human plasma

Gene Information

cow ... F2(280685)

Gene Information

cow ... F2(280685)

Gene Information

cow ... F2(280685)

Gene Information

human ... F2(2147)

specific activity

≥2,000 NIH units/mg protein (E1%/280 = 19.5)

specific activity

600-2,000 NIH units/mg protein (biuret)

specific activity

40-500 NIH units/mg protein (biuret)

specific activity

≥2800 NIH units/mg protein (E1%/280, 18.3)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

application(s)

diagnostic assay manufacturing

application(s)

diagnostic assay manufacturing

application(s)

-

application(s)

diagnostic assay manufacturing

mol wt

heavy chain ~33 kDa, light chain ~5 kDa

mol wt

heavy chain ~33 kDa, light chain ~5 kDa

mol wt

heavy chain ~33 kDa, light chain ~5 kDa

mol wt

37.4 kDa

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Biochem/physiol Actions

Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B.

Physical form

Lyophilized from saline sodium citrate buffer, pH 6.5

Analysis Note

Activity is expressed in NIH units obtained by direct comparison to a NIH Thrombin Reference Standard, Lot K.
The NIH assay procedure uses 0.2 mL of diluted plasma (1:1 with saline) as a substrate and 0.1 mL of thrombin sample (stabilized in a 1% buffered albumin solution) based on a modification of the method of Biggs. Only clotting times in the range of 15-25 seconds are used for determining thrombin concentrations.

Other Notes

Activity is expressed in NIH units obtained by direct comparison to a NIH thrombin reference standard.
View more information on thrombin at www.sigma-aldrich.com/enzymeexplorer.

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Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H334,H335

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000505578
0000505578
0000457427
0000457427
0000438051

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Rosaria Ottanà et al.
Bioorganic chemistry, 92, 103211-103211 (2019-09-07)
Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin and leptin signalling and is crucially involved in the development of type 2 diabetes mellitus, obesity, cancer and neurodegenerative diseases. Pursuing our efforts to identify PTP1B inhibitors endowed
Andrea Stöhr et al.
Journal of molecular and cellular cardiology, 63, 189-198 (2013-07-31)
Myosin-binding protein C (Mybpc3)-targeted knock-in mice (KI) recapitulate typical aspects of human hypertrophic cardiomyopathy. We evaluated whether these functional alterations can be reproduced in engineered heart tissue (EHT) and yield novel mechanistic information on the function of cMyBP-C. EHTs were
N J Royle et al.
Somatic cell and molecular genetics, 13(3), 285-292 (1987-05-01)
The gene for human prothrombin, or factor II (F2) has been assigned to 11p11-q12 by the combined use of a panel of somatic cell hybrid DNAs and in situ hybridization, using both cDNA and genomic probes. In addition, the cDNA
Marco Castelli et al.
The Journal of biological chemistry, 279(43), 44731-44739 (2004-07-31)
Mitogen-activated protein (MAP) kinases play a central role in controlling a wide range of cellular functions following their activation by a variety of extracellular stimuli. MAP kinase phosphatases (MKPs) represent a subfamily of dual specificity phosphatases, which negatively regulate MAP
U Seligsohn
Haemophilia : the official journal of the World Federation of Hemophilia, 18 Suppl 4, 161-165 (2012-06-29)
For patients affected by severe inherited platelet dysfunctions, e.g. Glanzmann thrombasthenia (GT) or Bernard-Soulier syndrome (BSS), platelet transfusion is frequently needed for controlling spontaneous bleeding, and is always needed when trauma occurs or surgery is performed. For the mild-to-moderate bleeding
View All Related Papers

Articles

Thrombin Factor IIa

Thrombin Factor IIa is an endolytic serine protease that selectively cleaves the Arg--Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

Protocols

Thrombin from Bovine Plasma

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

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