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Merck

R3250

Acetato de retinil

synthetic, matrix dispersion, 475,000-650,000 USP units/g

Sinónimos:

Acetato de retinol, Acetato de vitamina A

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Fórmula empírica (notación de Hill):
C22H32O2
Número CAS:
Peso molecular:
328.49
Beilstein:
1915439
Número CE:
Número MDL:
Código UNSPSC:
12352205
eCl@ss:
34058009
ID de la sustancia en PubChem:
NACRES:
NA.79

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origen biológico

synthetic

Nivel de calidad

Formulario

matrix dispersion

actividad específica

475,000-650,000 USP units/g

color

yellow

mp

57-58 °C

temp. de almacenamiento

−20°C

cadena SMILES

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+

Clave InChI

QGNJRVVDBSJHIZ-QHLGVNSISA-N

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Este artículo
R788246958R0300000
biological source

synthetic

biological source

synthetic

biological source

-

biological source

synthetic

form

matrix dispersion

form

solid or viscous liquid

form

-

form

solid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-10 to -25°C

storage temp.

−20°C

mp

57-58 °C

mp

57-58 °C

mp

57-58 °C

mp

57-58 °C

color

yellow

color

light yellow to dark yellow

color

-

color

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

-

Descripción general

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain. Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate.[1]

Aplicación

Retinyl acetate has been used:
  • a control diet to study its effect at different developmental periods in fish larvae[2]
  • to study its inhibitory effects on Mycobacterium avium subspecies paratuberculosis (MAP) strains[3]
  • as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk[4]

Acciones bioquímicas o fisiológicas

Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as required. Retinyl acetate is used in a wide range of biological applications.[1] It acts as a chemopreventive agent.[5] Retinyl acetate also has antineoplastic property.[6]

Forma física

Dispersion in cornstarch-gelatin matrix. Oil dispersible

Nota de análisis

Activity based on HPLC comparison to USP standard.

Pictogramas

Health hazard

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Aquatic Chronic 4 - Repr. 1B

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


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Certificados de análisis (COA)

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Visite la Librería de documentos

Laure A N Villeneuve et al.
The British journal of nutrition, 95(4), 677-687 (2006-03-31)
The effect of the feeding period on larval development was investigated in European sea bass larvae by considering the expression level of some genes involved in morphogenesis. Larvae were fed a control diet except during three different periods (period A:
Intake of high levels of vitamin A and polyunsaturated fatty acids during different developmental periods modifies the expression of morphogenesis genes in European sea bass (Dicentrarchus labrax)
Villeneuve LAN, et al.
The British Journal of Nutrition, 95(4), 677-687 (2006)
Therapeutic Use of Medicinal Plants and their Extracts:Phytochemistry and Bioactive Compounds (2018)
Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid
Udeani GO, et al.
Cancer Research, 57(16), 3424-3428 (1997)
Effect of combined selenium and retinyl acetate treatment on mammary carcinogenesis
Thompson HJ, et al.
Cancer Research, 41(4), 1413-1416 (1981)

Preguntas

  1. What is the solubility information for this product? It is not dissolved in hexane, heptane, acetone, isopropyl alcohol, water, and absolute ethanol; even left overnight on stir plate.

    1 respuesta
    1. R3250 is classified as a matrix dispersion. This product contains gelatin, sugar, modified food starch, and other components to make it convenient as an "oil dispersible material," which will not dissolve in chloroform. The gelatin and starch components in this product would not be soluble but will be dispersed or suspended in the oil. For a soluble retinol acetate product, recommended Product No. is R4632, Retinol Acetate all trans, which is soluble in chloroform (50 mg/ml), yielding a clear, yellow-green solution. Product No. R4632 is also soluble in ethanol.

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