A graphene oxide-photosensitizer complex as an enzyme-activatable theranostic agent.

A graphene oxide-photosensitizer complex as an enzyme-activatable theranostic agent.

Chemical communications (Cambridge, England) (2013-01-04)

Youngnam Cho, Hyunjin Kim, Yongdoo Choi

RESUMEN

The development of a target-activatable "smart" platform with high-affinity and specificity is of great importance for a wide range of biomedical applications. Here, we attempted to develop a new enzyme-activatable graphene oxide-photosensitizer complex as a biologically tunable theranostic agent, making it promising for near-infrared (NIR) fluorescence imaging and photo-induced cancer therapy.

MATERIALES

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H3506

Sigma-Aldrich

Hialuronidasa from bovine testes, Type I-S, lyophilized powder, 400-1000 units/mg solid

H3884

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Hialuronidasa from bovine testes, Type IV-S, lyophilized powder (essentially salt-free), 750-3000 units/mg solid

H4272

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Hialuronidasa from bovine testes, Type IV-S, powder, suitable for mouse embryo cell culture, 750-3000 units/mg solid

H6254

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Hyaluronidase from sheep testes, Type V, lyophilized powder, ≥1,500 units/mg solid

H3757

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Hialuronidasa from bovine testes, Type VIII, lyophilized powder, 300-1,000 U/mg

H2126

Sigma-Aldrich

Hyaluronidase from sheep testes, Type II, lyophilized powder, ≥300 units/mg solid

H3631

Sigma-Aldrich

Hialuronidasa from bovine testes, Type VI-S, lyophilized powder, 3,000-15,000 units/mg solid