Buffer Filtration

Capsule and cartridge filters for processing buffers

Biomanufacturing requires large volumes of buffers for different steps in downstream processing, with filter selection highly dependent on the needs of the specific process step. For non-critical steps we offer bioburden reduction filters for superior process economics, while our sterilizing-grade buffer filters deliver fast flow and extended throughput for superior process efficiency. For some biomanufacturing operations, our virus retentive filters may be the best option for buffer filtration to achieve process safety.

All our filters are fully scalable from lab-scale process development tools to pilot and production scale manufacturing, with most offered in both single-use, gamma ready capsule and cartridge formats. In addition, each filter is available with several connection options to provide flexibility for your specific process needs.

  • Milligard® PES filters contain two layers of polyethersulfone (PES) membrane and reduce bioburden while providing broad chemical compatibility. Milligard® PES 1.2/0.2 µm nominal filters typically provide ≥ 6.0 log removal of Brevundimonas diminuta, while Milligard® PES 1.2/0.45 µm filters typically provide ≥ 6.0 log removal of Serratia marcescens.
  • 0.22 µm Durapore® filters contain a single layer of 0.22 µm polyvinylidene fluoride (PVDF) membrane and are low-binding, non fiber releasing with low extractables. Each filter is integrity tested during manufacturing.
  • Viresolve® Barrier capsule filters contain virus retentive PES membranes and offer high flux virus filtration. These filters offer ≥ 3.0 log removal of parvovirus, ≥ 6.0 log removal of mycoplasma and sterilizing-grade performance. Each filter is integrity tested during manufacturing.

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Regulatory Compliance

Complementing our product portfolio, the Emprove® Program consolidates comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.