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Solubility and Dissolution Enhancement Via Formulation

Our overview of API solubility and dissolution enhancement methods can help you decide between the many options to take during formulation.

Water Determination in Liquefied Petroleum Gas using GC BID and Ionic Liquid Column Watercol™

Using Watercol™ GC columns in conjunction with GC-BID can provide a reliable and practical option for Water determination in petrochemical feedstocks.

Renewable Electricity Toolkit

The Renewable Electricity Supplier Toolkit helps suppliers learn renewable electricity basics and how to bring projects to life.

Transforming the Biopharma Supply Chain and Analytics Capabilities with eData

An essential step in the progress towards Pharma 4.0 is the conversion of paper-based data to an electronic format, allowing it to be transferred, received, and available at the right time, in the right place, by those who need it.

Membrane Prefilters Improve Sterilizing Filter Capacity and Process Economics in Bioprocessing

Prefilters can be used throughout bioprocessing to remove to remove particulates, improve quality and protect sterilizing filters and downstream unit operations.

Viral Safety in Bioprocessing

Viral safety in bioprocessing relies on a framework of (1) preventing contamination, (2) detecting contamination, and (3) removing or inactivating viral contaminants.

Sterilizing Grade Filtration Unit Operations for Plasmid DNA Processes

We discuss the final filtration step of plasmid DNA manufacturing and its key considerations and challenges. Download our free pDNA downstream purification eBook or ask our experts.

Single-Pass Tangential Flow Filtration Implementation and Scaling

Get practical guidance on using single-pass tangential flow filtration in your downstream process and scaling between capsules and cassettes.

Tangential Flow Filtration in Downstream Bioprocessing

There are many options for tangential flow filtration (TFF) in downstream bioprocessing from multi-use to single-use TFF or batch TFF and single-pass TFF.

Viscosity Reduction in High Concentration TFF

This overview describes how use of viscosity-reducing excipients can address viscosity challenges in high concentration tangential flow filtration (TFF) and improve process economics.

Tangential Flow Filtration in the Antibody Drug Conjugate (ADC) Manufacturing Process

Find best practices for using Pellicon® Capsules in ADC processing as well as data from two studies using Pellicon® Capsules and Pellicon® cassettes in the ADC manufacturing process.

Heterocycle and Cyclic Peptide Formation with N-(isocyamino)triphenylphosphorane (Pinc)

Isocyanides are widely used reagents in organic synthesis, with applications ranging from materials science to drug discovery.

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Overcoming Aggregation in Solid-phase Peptide Synthesis

The ease of assembly of a given peptide sequence is hard to predict, which makes peptide synthesis challenging. Review methods and reagents for avoiding aggregation in solid-phase peptide synthesis.

Solving Aspartimide Formation in Fmoc SPPS with Fmoc-Asp(OBno)-OH

Aspartimide formation 1,2 is caused by repeated exposure of aspartic acid-containing sequences to bases like piperidine and can result ultimately in the generation of 9 different by-products.

Peptide Coupling Reagents Guide

Novabiochem® coupling reagents for in situ activation are fast-reacting and compatible with various amino acids.

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

Proline Derivatives and Analogs

Proline analogues are promising candidates for tuning the biological, pharmaceutical, or physicochemical properties of naturally occuring, as well as de novo designed, linear, and, cyclic peptides.

Selecting Orthogonal Building Blocks

Novabiochem® offers orthogonally protected amino acids for peptide synthesis, including cyclic and branched peptides.

Trifunctional Probe Building Blocks

In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.

Unnatural Amino Acids for Peptide Synthesis

Unnatural amino acids, the non-proteinogenic amino acids that either occur naturally or are chemically synthesized, are becoming more and more important as tools for modern drug discovery research.

Micro Photochemical Reactor

Photocatalysis in organic synthesis has grown with innovative methods using visible light, contributing to new research.

Nicewicz Photoredox Catalysts for Anti-Markovnikov Alkene Hydrofunctionalization

Explore Nicewicz Photoredox catalysts—photoexcitable acridinium salts for efficient, metal-free anti-Markovnikov hydrofunctionalizations.

Reducing Organic Photoredox Catalysts for Visible Light-Driven Polymer and Small Molecule Synthesis

Photoredox catalysis is a powerful synthetic methodology to form challenging covalent bonds using light irradiation. It is effective for light-driven polymer and small molecule synthesis.

KitAlysis™ Photocatalysis Reaction Screening Kit

PhotoKitAlysis Reaction Kit aids in cross-coupling reactions, offering pre-weighed components for optimization.

Scale-Up Guide: Photocatalysis Reaction

Scale-Up Guide for Photocatalysis Reaction to best enable scale-up success with High-Throughput Screening Kit.

Photoredox Iridium Catalyst for SET Cross-Coupling

Effective Csp2- and Csp-hybridized coupling reactions established for catalysis, expanding to multi-step Csp3-coupling.

Visible-light Photoredox Catalysis

The application of radical chemistry towards organic synthesis is well-developed and wide-reaching, though often hampered by a dependence on toxic radical initiators.

Degrader Building Blocks with IAP In Silico-Derived Ligands

Targeted protein degradation reduces disease-relevant proteins in cells using small molecules, hijacking endogenous proteolysis systems.

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

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