SCP0093

Caspase Inhibitor

Name: Caspase Inhibitor
Brand: SIGMA
Price: 248 GBP

≥95% (HPLC)

Synonym(s):

Ac-LETD-CHO, caspase 8 inhibitor, caspase 9 inhibitor

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5 MG

£248.00

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₃₄N₄O₁₀

Molecular Weight:

502.52

NACRES:

NA.32

UNSPSC Code:

12352200

Key Documents

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Product Name

Caspase Inhibitor, ≥95% (HPLC)

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

storage temp.

−20°C

Gene Information

human ... CASP8(841), CASP9(842)

Related Categories

Bioactive Small Molecule Inhibitors

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1 of 4

This Item	SCP0095	627610	SCP0094
Sigma-Aldrich SCP0093 Caspase Inhibitor	Sigma-Aldrich SCP0095 Caspase Inhibitor	Sigma-Aldrich 627610 Caspase Inhibitor I	Sigma-Aldrich SCP0094 Caspase Inhibitor
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay -	assay ≥95% (HPLC)
Gene Information human ... CASP8(841), CASP9(842)	Gene Information human ... CASP9(842)	Gene Information -	Gene Information human ... CASP10(843), CASP6(839), CASP8(841), CASP9(842)
form lyophilized	form lyophilized	form solid	form lyophilized
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
storage condition protect from light	storage condition protect from light	storage condition OK to freeze, desiccated	storage condition protect from light
composition Peptide Content, ≥80%	composition Peptide Content, ≥80%	composition -	composition Peptide Content, ≥80%

Biochem/physiol Actions

The peptide Ac-Leu-Glu-Thr-Asp-al, or Ac-LETD-CHO, is a known caspase inhibitor. Ac-LETD-CHO has been reported to exert inhibitory effects on caspase 8[1] and on caspase 9.

Application

Caspase inhibitor Ac-LETD-CHO has been used to inhibit caspase-8.[1]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

LG0444

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Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells.

Jie Shi et al.

Biochemical pharmacology, 75(9), 1729-1742 (2008-04-02)

Indirubin-3'-monoxime (I3M) is a derivative of indirubin, an active component from a Chinese medicinal recipe with known anti-cancer function. I3M has been well established as a cyclin-dependent kinase (CDK) inhibitor, while the molecular mechanism underlying I3M-induced apoptosis has not been

Apoptotic Regulation of Caspase Activity

Martinova, E.A., et al.

Russian J. Bioorg. Chem., 29, 471-495 (2003)

Enteric glial cells counteract Clostridium difficile Toxin B through a NADPH oxidase/ROS/JNK/caspase-3 axis, without involving mitochondrial pathways

Lara M

Scientific Reports (2017)

Preventive Effects of Food Components on Caspase-8-Mediated Apoptosis Induced by Dietary Carcinogen, Trp-P-1, in Rat Mononuclear Cells

Hashimoto, T., et al.

ACS Symp. Ser., 851, 128-140 (2003)

Cell death signal by glycine- and proline-rich plant glycoprotein is transferred from cytochrome c and nuclear factor kappa B to caspase 3 in Hep3B cells.

Sei-Jung Lee et al.

The Journal of nutritional biochemistry, 19(3), 166-174 (2007-06-26)

This study was carried out to investigate the apoptotic effects of glycine- and proline-rich glycoprotein [Solanum nigrum Linne (SNL) glycoprotein, 150-kDa] isolated from SNL, which has been used as an antipyretic and anticancer agent in Korean herbal medicine. We found

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Caspase Inhibitor