The product was lyophilized from a mixture of water and acetonitrile containing 0.1 % trifluoroacetic acid (the solvent used to purify the product by reverse-phase chromatography).
SCP0094
Caspase Inhibitor
Synonym(s):
Ac-AEVD-CHO, caspase 6 inhibitor, caspase 8 inhibitor
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5 MG
£254.00
£254.00
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About This Item
Empirical Formula (Hill Notation):
C19H30N4O9
Molecular Weight:
458.46
NACRES:
NA.32
UNSPSC Code:
12352200
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assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥80%
storage condition
protect from light
storage temp.
−20°C
Gene Information
human ... CASP10(843), CASP6(839), CASP8(841), CASP9(842)
Related Categories
1 of 4
This Item | SCP0093 | 627610 | SCP0095 |
|---|---|---|---|
| assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay - | assay ≥95% (HPLC) |
| Gene Information human ... CASP10(843), CASP6(839), CASP8(841), CASP9(842) | Gene Information human ... CASP8(841), CASP9(842) | Gene Information - | Gene Information human ... CASP9(842) |
| form lyophilized | form lyophilized | form solid | form lyophilized |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| storage condition protect from light | storage condition protect from light | storage condition OK to freeze, desiccated | storage condition protect from light |
| composition Peptide Content, ≥80% | composition Peptide Content, ≥80% | composition - | composition Peptide Content, ≥80% |
Application
Caspase Inhibitor has been used to study the specificity of the CIL-1 (desglucoanagalloside B) interaction with the caspase 3/7 system.[1]
Biochem/physiol Actions
The peptide Ac-Ala-Glu-Val-Asp-al, or Ac-AEVD-CHO, is an inhibitor of Group III caspases. It acts upon caspases-6, 8, 9, and 10, with particular effectiveness on caspase-6 and caspase-8. The use of Ac-AEVD-CHO in several apotosis studies has been reported.
General description
Currently, there are 13 caspases recognized in mammals. Caspases are classified as initiators and effectors. Caspase 8 belongs to the class of initiators. It possesses a prodomain at the terminal and contains the death effector domain which serves as protein-protein interaction motif for caspase 8. With respect to substrate specificity, caspase 8 is classified as a member of group III. It specifically recognizes the (I/L/V) EXD sequence on the substrate.[2]
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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