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Merck

702153

羟基磷灰石

nanoparticles, dispersion, 10 wt. % in H2O, <200 nm particle size (BET)

别名:

Calcium hydroxide phosphate, Calcium hydroxylapatite, Calcium hydroxyphosphate, Nano hydroxyapatatite, Pentacalcium hydroxide triphosphate

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关于此项目

线性分子式:
[Ca5(OH)(PO4)3]x
化学文摘社编号:
12167-74-7
分子量:
502.31
NACRES:
NA.23
PubChem Substance ID:
329762350
UNSPSC Code:
12352302
MDL number:
MFCD00010904
Form:
dispersion
nanoparticles

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产品名称

羟基磷灰石, nanoparticles, dispersion, 10 wt. % in H2O, <200 nm particle size (BET)

InChI

1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10

SMILES string

[Ca++].[Ca++].[Ca++].[Ca++].O[Ca+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

InChI key

XYJRXVWERLGGKC-UHFFFAOYSA-D

form

dispersion
nanoparticles

contains

≤0.025 wt. % dispersant (non-metal based)

concentration

10 wt. % in H2O

surface area

14.3 m2/g , typical

particle size

<200 nm (BET)

pH

4-6

density

1.038 g/mL at 25 °C

Quality Level

100

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相关类别

Application

羟基磷灰石可被用于：
  • 一种替代骨的植入材料，因为其化学成分与 骨中无机盐成分相似且有骨诱导特性。
  • 基因和药物载体，因为它具有封装能力和 对许多药物、蛋白有亲和力。
  • 对pH响应的微粒乳化剂。

Features and Benefits

  • 生物相容的
  • 骨传导的
  • 在 胜利条件下稳定
  • 高机械强度高强度

General description

羟基磷灰石(HAP)是一种骨传导生物陶瓷材料，它具有独特的性能可以直接与活体组织结合。它可以通过多种技术制备，如溶液-凝胶法、水热法、多重乳化法、仿生沉积法和电沉积法。

Legal Information

Engi-Mat Co.产品。

存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCQ7691
MKCS4260
MKCP8250
MKCN6392
MKCL6094

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Martin P Reichhardt et al.
Life science alliance, 3(4) (2020-02-27)
The scavenger receptor cysteine-rich (SRCR) family of proteins comprises more than 20 membrane-associated and secreted molecules. Characterised by the presence of one or more copies of the ∼110 amino-acid SRCR domain, this class of proteins have widespread functions as antimicrobial
Xi Chen et al.
The Journal of biological chemistry, 289(16), 11162-11174 (2014-03-13)
Calcium phosphate precipitates (CPPs) form complexes with DNA, which enter cells via endocytosis. Under this condition CPPs induce autophagy via the canonic autophagy machinery. Here we showed that CPP-induced autophagy was also dependent on endocytosis as the process was significantly
Ehud Segal et al.
PloS one, 4(4), e5233-e5233 (2009-04-22)
There is an immense clinical need for novel therapeutics for the treatment of angiogenesis-dependent calcified neoplasms such as osteosarcomas and bone metastases. We developed a new therapeutic strategy to target bone metastases and calcified neoplasms using combined polymer-bound angiogenesis inhibitors.
Layal Safa et al.
Biochimie, 103, 80-88 (2014-04-22)
Replication protein A (RPA) is a single-stranded DNA binding protein that plays an essential role in telomere maintenance. RPA binds to and unfolds G-quadruplex (G4) structures formed in telomeric DNA, thus facilitating lagging strand DNA replication and telomerase activity. To
Lian-Hua Xu et al.
Applied microbiology and biotechnology, 99(7), 3081-3091 (2014-10-25)
Diclofenac is a nonsteroidal anti-inflammatory drug. It undergoes hydroxylation by mammalian cytochrome P450 enzymes at 4'- and/or 5'-positions. A bacterial P450 enzyme, CYP105D7 from Streptomyces avermitilis, has been shown to catalyze hydroxylation of 1-deoxypentalenic acid and an isoflavone daidzein. Here
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