324410
Dynasore
≥98% (HPLC), solid, dynamin inhibitor, Calbiochem®
别名:
发动蛋白抑制剂I ，Dynasore
产品名称
发动蛋白抑制剂I ，Dynasore, The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.
品質等級
化驗
≥98% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
pale yellow
溶解度
DMSO: 16 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
SMILES 字串
N(\N=C\c3cc(c(cc3)O)O)C(=O)c1cc2c(cc1O)cccc2
InChI
1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
InChI 密鑰
SYNDQCRDGGCQRZ-VXLYETTFSA-N
相关类别
一般說明
一种细胞可渗透的缩氨基脲化合物，可抑制发动蛋白1/2（IC50 ~15 µM）和Drp1的GTPase活性，对其他两种小GTPases（MxA和Cdc42）没有显著的影响。Dynasore已被用来阐明发动蛋白在网格蛋白包被的和突触小泡介导的内吞作用中的作用。抑制相对于GTP是非竞争性的，并且抑制剂靶位点可能位于GTPase结构域中。显示抑制从质膜上去除wt和ΔF508-CFTR。
包裝
用惰性气体包装
準備報告
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他說明
Young, A., et al. 2009.Biochem.J., In press.
Nankoe, S.R., and Sever, S. 2006.Trends Cell Biol.16, 607.
Newton, A.J., et al. 2006.Proc.Natl.Acad.Sci. USA103, 17955.
Macia.E., et al. 2006.Dev.Cell10, 839.
Nankoe, S.R., and Sever, S. 2006.Trends Cell Biol.16, 607.
Newton, A.J., et al. 2006.Proc.Natl.Acad.Sci. USA103, 17955.
Macia.E., et al. 2006.Dev.Cell10, 839.
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法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
毒性：环境危害（N）
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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