382120

Histone Acetyltransferase Activator, CTB

The Histone Acetyltransferase Activator, CTB, also referenced under CAS 451491-47-7, modulates the biological activity of Histone. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 别名: Histone Acetyltransferase Activator, CTB, EP300 Activator, E1A binding protein 300 Activator, N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator
• 经验公式（希尔记法）: C₁₆H₁₃ClF₃NO₂
• 化学文摘社编号: 451491-47-7
• 分子量: 343.73
• MDL號碼: MFCD02356522
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥90% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: ethanol: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl
• InChI: 1S/C16H13ClF3NO2/c1-2-23-14-6-4-3-5-11(14)15(22)21-10-7-8-13(17)12(9-10)16(18,19)20/h3-9H,2H2,1H3,(H,21,22)
• InChI 密鑰: YDXZSNHARVUYNM-UHFFFAOYSA-N

说明

一般說明

A benzamide compound that activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein 300 in a dose-dependent manner (~6-fold of basal HAT activity of recombinant human p300 toward purified HeLa core histones in the presence of 250 µM CTB). SERS spectrum indicates that CTB interacts with p300 preferentially via the amide groups of the α-helix and β-sheets, resulting in altered enzyme conformation, which presumably accounts for the increased enzymatic activity.

包裝

Packaged under inert gas

準備報告

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Mantelingu, K., et al. 2007. J. Phys. Chem. B111, 4527.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Toxicity: Standard Handling (A)

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2