ABE1341

Anti-ZBTB38

from rabbit

• 别名: Zinc finger and BTB domain-containing protein 38
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 物種活性: human
• 包裝: antibody small pack of 25 μL
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI登錄號: NP_001073881
• UniProt登錄號: Q8NAP3
• 目標翻譯後修改: unmodified
• 基因資訊: human ... ZBTB38(253461)

说明

一般說明

Zinc finger and BTB domain-containing protein 38 (UniProt: Q8NAP3, ZBTB38) is encoded by the ZBTB38 gene (Gene ID: 253461) in human. ZBTB38 is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5′-CGCG-3′, but can also bind to E-box elements (5′-CACGTG-3′). It can also bind specifically to a single methyl-CpG pair and represses transcription in a methyl-CpG-dependent manner. ZBTB38 protein is reported to play an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner and is shown to repress expression of MCM10, which plays an important role in DNA-replication. It is also believed to be involved in the differentiation and/or survival of late post-mitotic neurons. ZBTB38 protein contains ten C2H2-type zinc fingers and its BTB (Broad-Complex, Tramtrack and Bric a brac) domain is localized in the amino acids 33-100. However, the BTB domain is not required for its activation. ZBTB38 is down-regulated under conditions of endoplasmic reticulum (ER) stress, which promotes ER stress-associated apoptosis in human bone marrow neuroblastoma cells. In mice subjected to spinal cord injury (SCI) a repression of ZBTB38 is observed and this is linked to reduced secondary tissue damage after SCI. (Ref.:Cai, Y., et al. (2017). Oncotarget 8(28); 45356-45366).

~170 kDa observed; 134.26 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

免疫原

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to 20 amino acids from the C-terminus region of human Zinc finger and BTB domain-containing protein 38.

應用

Anti-ZBTB38 Antibody, Cat. No. ABE1341, is a highly specific rabbit polyclonal antibody that targets ZBTB38 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected ZBTB38 in human testis and human kidney tissue sections.

Research Category
Epigenetics & Nuclear Function

生化／生理作用

This rabbit polyclonal antibody specifically detects Zinc finger and BTB domain-containing protein 38 in human cells. It targets an epitope within 20 amino acids from the C-terminus region.

外觀

Affinity Purified

Format: Purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

準備報告

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Evaluated by Western Blotting in HeLa cell nuclear extract.

Western Blotting Analysis: A 1:500 dilution of this antibody detected ZBTB38 in HeLa cell nuclear extract.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable