P1499
紫檀芪
≥97% (HPLC), apoptosis inducer, solid
别名:
紫檀, 3,5-二甲氧基-4′-羟基茋, 4-[(1E)-2-（3,5-二甲氧基苯基）乙烯基] 苯酚
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关于此项目
经验公式（希尔记法）:
C16H16O3
化学文摘社编号:
分子量:
256.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
紫檀芪, ≥97% (HPLC), solid
SMILES string
COc1cc(OC)cc(\C=C\c2ccc(O)cc2)c1
InChI key
VLEUZFDZJKSGMX-ONEGZZNKSA-N
InChI
1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
assay
≥97% (HPLC)
form
solid
storage condition
protect from light
solubility
DMSO: >20 mg/mL
H2O: insoluble
storage temp.
2-8°C
Quality Level
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相关类别
Biochem/physiol Actions
紫檀芪对几种恶性肿瘤具有抗癌作用，因此可作为活性抗癌药物。在雌激素受体阳性和阴性乳腺癌细胞系中，它可激活细胞凋亡并抑制细胞活性。
抗氧化、抗增殖、细胞凋亡诱导、抗高血糖、抗糖尿病。
Disclaimer
空气敏感性
General description
紫檀芪(反式-3,5-二甲氧基-4-羟基芪)抗氧化剂是白藜芦醇的类似物，存在于蓝莓、树木和几种葡萄中。
Application
紫檀芪已用于：
- 研究其抗氧化应激活性以及在核转录因子E2相关因子2(Nrf2)-抗氧化反应元件(ARE)信号转导通路中的调节作用
- 确定其对激素耐受性乳腺癌细胞雌激素受体α(ERα)转录激活的影响
- 通过MTT(3-[4,5-二甲基噻唑-2-基]-2,5二苯基四氮唑溴化物)活力检测法研究其对人表皮样癌细胞(A-431)中2-氯乙基乙基硫醚(CEES)的细胞毒性的影响。
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 2 - Eye Dam. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Pino M A, et al.
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Journal of agricultural and food chemistry, 59(20), 10964-10970 (2011-09-23)
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