SAB4503087
Anti-WASP antibody produced in rabbit
affinity isolated antibody
别名:
IMD2, WAS, Wiskott-Aldrich syndrome protein, Wiskott-Aldrich syndrome protein homolog
产品名称
Anti-WASP antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 52 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... WAS(7454)
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
General description
WASP (Wiskott-Aldrich syndrome protein) codes for a 65 kDa protein, localized to the cytoplasm. The WASP gene is mapped to human chromosome Xp11.23.
Anti-WASP Antibody detects endogenous levels of total WASP protein.
Biochem/physiol Actions
WASP (Wiskott-Aldrich syndrome protein) is regarded as a scaffold protein that integrates cell surface signals to actin cytoskeleton. WASP gene regulates actin polymerization, contributing to T-cell activation and migration. Neural WASP is known to regulate a variety of cellular processes including pathogen infection, vesicle trafficking, invadopodium formation and growth, and neurite extension. Mutation in this gene causes WAS, a X-linked recessive immunodeficiency disorder.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Immunogen
The antiserum was produced against synthesized peptide derived from human WASP.
Immunogen Range: 256-305
Immunogen Range: 256-305
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion
Frugtniet BA, et al.
BMC Cancer, 17(1), 224-224 (2017)
X-Linked Syndrome of Polyendocrinopathy, Immune Dysfunction, and Diarrhea Maps to Xp11.23-Xq13.3
Bennett CL, et al.
American Journal of Human Genetics, 66(2), 461-468 (2000)
Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α
Jain N, et al.
Scientific Reports, 5, 15031-15031 (2015)
Novel WASP mutation in a patient with Wiskott-Aldrich syndrome: Case report and review of the literature.
Eghbali M, et al.
Allergologia et Immunopathologia, 44(5), 450-454 (2016)
Sudha Kumari et al.
The EMBO journal, 39(5), e102783-e102783 (2020-01-03)
When migratory T cells encounter antigen-presenting cells (APCs), they arrest and form radially symmetric, stable intercellular junctions termed immunological synapses which facilitate exchange of crucial biochemical information and are critical for T-cell immunity. While the cellular processes underlying synapse formation
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持