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Merck

04-299

Anti-phospho-Insulin Receptor (Tyr 1150/1151) Antibody, clone 10C3

clone 10C3, Upstate®, from mouse

Synonym(s):

INSR

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-phospho-Insulin Receptor (Tyr 1150/1151) Antibody, clone 10C3, clone 10C3, Upstate®, from mouse

biological source

mouse

antibody form

purified antibody

antibody product type

primary antibodies

clone

10C3, monoclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000208.2
NM_001079817.1

UniProt accession no.

P06213

shipped in

wet ice

target post-translational modification

phosphorylation (pTyr1150/pTyr1151)

Quality Level

100

Gene Information

human ... INSR(3643)

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04-30005-110805-1066
Anti-phospho-Insulin Receptor (Tyr 1150/1151) Antibody, clone 10C3 clone 10C3, Upstate®, from mouse

Sigma-Aldrich

04-299

Anti-phospho-Insulin Receptor (Tyr 1150/1151) Antibody, clone 10C3

Anti-phospho-Insulin Receptor (Tyr 1322) Antibody, clone 21G12 clone 21g12, Upstate®, from mouse

Sigma-Aldrich

04-300

Anti-phospho-Insulin Receptor (Tyr 1322) Antibody, clone 21G12

Anti-Insulin Antibody, clone1 clone MAB1, from mouse, purified by affinity chromatography

Sigma-Aldrich

05-1108

Anti-Insulin Antibody, clone1

Anti-Insulin Antibody, clone E11D7 clone E11D7, from mouse

Sigma-Aldrich

05-1066

Anti-Insulin Antibody, clone E11D7

clone

10C3, monoclonal

clone

21g12, monoclonal

clone

MAB1, monoclonal

clone

E11D7, monoclonal

species reactivity

human

species reactivity

canine, human, mouse

species reactivity

human

species reactivity

human

antibody form

purified antibody

antibody form

purified antibody

antibody form

affinity isolated antibody

antibody form

purified antibody

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

UniProt accession no.

P06213

UniProt accession no.

P06213

UniProt accession no.

P01308

UniProt accession no.

P01308

technique(s)

activity assay: suitable, western blot: suitable

technique(s)

ELISA: suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable (paraffin)

technique(s)

ELISA: suitable, immunohistochemistry: suitable (paraffin)

Analysis Note

Control
Includes pervanadate treated HEK293 lysate as a positive control
Routinely evaluated by immunoblot.

Application

Detect phospho-Insulin Receptor (Tyr 1150/1151) using this Anti-phospho-Insulin Receptor (Tyr 1150/1151) Antibody, clone 10C3 validated for use in EA & WB.

Biochem/physiol Actions

Recognizes phosphorylated domain of Insulin receptor on Tyrosine 1150/1151.

General description

97 kDa

Immunogen

KLH-conjugated synthetic peptide encompassing the surrounding amino acids of Tyrosine 1150/1151 on phosphorylated insulin receptor.

Physical form

Format: Purified
In 1 mL of PBS containing 0.09% sodium azide, PEG, and sucrose and 50% glycerol.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Natalie N Rizk et al.
Fertility and sterility, 86(4 Suppl), 1217-1222 (2006-09-12)
To determine whether the insulin receptor (IR), insulin-like growth factor-I receptor (IGF-IR), and IGF-I are expressed differentially in fibroblasts isolated from normal peritoneal and adhesion tissue before and after 24-hour treatment with increasing glucose concentrations. Prospective experimental study. University medical
Qiu-yan Wang et al.
The FEBS journal, 274(2), 526-538 (2007-01-19)
Two H7721 human hepatocarcinoma cell lines showing moderate and high expression of alpha1,3-fucosyltransferase (FucT)-VII cDNA were established and designated FucTVII-M and FucTVII-H, respectively. In alpha1,3-FucT-VII-transfected cells, expression of insulin receptor (InR) alpha- and beta subunits and epidermal growth factor receptor
Atsumi Tsuji-Hosokawa et al.
Pediatric diabetes, 18(8), 917-924 (2017-02-10)
Defects of the insulin receptor gene ( INSR ) cause wide spectra of congenital insulin resistance. Monoallelic defects result in milder insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN, type A). Whereas, leprechaunism (Donahue syndrome), the most severe condition with lethality
Adrián Martín-Segura et al.
Aging cell, 18(3), e12932-e12932 (2019-03-19)
In the brain, insulin plays an important role in cognitive processes. During aging, these faculties decline, as does insulin signaling. The mechanism behind this last phenomenon is unclear. In recent studies, we reported that the mild and gradual loss of
Rita Slaaby et al.
The Journal of biological chemistry, 281(36), 25869-25874 (2006-07-13)
Insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) are both from the same subgroup of receptor tyrosine kinases that exist as covalently bound receptor dimers at the cell surface. For both IR and IGF-IR, the most described forms
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