B4312

BTK, active, His tagged human

Name: BTK, active, His tagged human
Brand: SIGMA
Price: 2234 ILS

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

AGMX1, AT, ATK, BPK, IMD1, PSCTK, XLA

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10 μG

₪2,234.00

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About This Item

NACRES:

NA.32

UNSPSC Code:

12352200

Key Documents

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Product Name

BTK, active, His tagged human, PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO^® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

37-49 nmol/min·mg

mol wt

~78 kDa

solubility

water: soluble

UniProt accession no.

Q06187

application(s)

life science and biopharma

shipped in

dry ice

storage temp.

−70°C

Quality Level

100

Gene Information

human ... BTK(695)

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Show Differences

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This Item	SRP0330	I6160	M8322
Sigma-Aldrich B4312 BTK, active, His tagged human	Sigma-Aldrich SRP0330 BTK active human	Sigma-Aldrich I6160 ITK (352-end), active, GST tagged human	Sigma-Aldrich M8322 MAPKAPK3, active, GST tagged human
biological source human	biological source human	biological source -	biological source -
Gene Information human ... BTK(695)	Gene Information human ... BTK(695)	Gene Information human ... ITK(3702)	Gene Information human ... MAPKAPK3(7867)
assay ≥70% (SDS-PAGE)	assay ≥80% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)
specific activity 37-49 nmol/min·mg	specific activity -	specific activity 49-67 nmol/min·mg	specific activity 541-731 nmol/min·mg
application(s) life science and biopharma	application(s) -	application(s) -	application(s) -
form buffered aqueous glycerol solution	form aqueous solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution

Biochem/physiol Actions

BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors.Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments.

Physical form

Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H315,H319,H360D

pcodes

P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)

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Therapeutic potential of inhibiting Bruton's tyrosine kinase, (BTK).

A O Vassilev et al.

Current pharmaceutical design, 10(15), 1757-1766 (2004-06-08)

BTK (Bruton's tyrosine kinase) is a member of the TEC family of tyrosine kinases that plays a central but diverse modulatory role in various cellular processes. The unique role of BTK in a multitude of signaling pathways, its function as

Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.

G Cheng et al.

Proceedings of the National Academy of Sciences of the United States of America, 91(17), 8152-8155 (1994-08-16)

Bruton's tyrosine kinase (Btk) is a recently described B-cell-specific tyrosine kinase. Mutations in this gene lead to human X chromosome-linked agammaglobulinemia and murine X-linked immunodeficiency. Although genetic evidence strongly suggests that Btk plays a crucial role in B-lymphocyte differentiation and

p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma.

Federica Giordano et al.

Journal of experimental & clinical cancer research : CR, 38(1), 260-260 (2019-06-16)

Lung cancer is still the main cause of cancer death worldwide despite the availability of targeted therapies and immune-checkpoint inhibitors combined with chemotherapy. Cancer cell heterogeneity and primary or acquired resistance mechanisms cause the elusive behaviour of this cancer and

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