The dry powder form allows for the preparation of Congo Red for various uses. The recommended dry dye for ordering is C6277 is currently undergoing BSC certification. Congo Red is a dye used for various staining procedures, mostly for staining of amyloid.
C6277
Congo Red
Dye content, ≥85%, certified by the Biological Stain Commission, powder
Synonym(s):
Congo Red 4B, Cosmos Red, Cotton Red B, Cotton Red C, Direct Red 28, Direct Red R, Direct Red Y
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25 G
₪1,365.00
About This Item
Empirical Formula (Hill Notation):
C32H22N6Na2O6S2
CAS Number:
Molecular Weight:
696.66
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
EC Number:
209-358-4
MDL number:
Colour Index Number:
22120
Beilstein/REAXYS Number:
3894858
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Product Name
Congo Red, certified by the BSC, BioXtra
InChI key
IQFVPQOLBLOTPF-HKXUKFGYSA-L
InChI
1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2/b37-35+,38-36+;;
SMILES string
[Na+].[Na+].Nc1c(cc(c2ccccc12)S([O-])(=O)=O)\N=N\c3ccc(cc3)-c4ccc(cc4)\N=N\c5cc(c6ccccc6c5N)S([O-])(=O)=O
agency
certified by the BSC
product line
BioXtra
form
powder
composition
Dye content, ≥85%
technique(s)
microbe id | staining: suitable
mp
>360 °C (lit.)
solubility
H2O: 10 mg/mL
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Quality Level
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This Item | C6767 | S4261 | S4136 |
|---|---|---|---|
| grade certified by the Biological Stain Commission | grade - | grade certified by the Biological Stain Commission | grade certified by the Biological Stain Commission |
| technique(s) microbe id | staining: suitable | technique(s) titration: suitable | technique(s) - | technique(s) - |
| application(s) diagnostic assay manufacturing | application(s) diagnostic assay manufacturing | application(s) diagnostic assay manufacturing | application(s) diagnostic assay manufacturing |
| form powder | form powder | form powder | form powder |
| solubility H2O: 10 mg/mL | solubility H2O: 1 mg/mL | solubility - | solubility toluene: 1 mg/mL, clear, red |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
Application
Certified for use as a counterstain for alum based hematoxylin and in the Highman or the Churukian modification of Puchtler′s amyloid stain.
Biochem/physiol Actions
Congo red is a benzidine-based anionic diazo dye.[4] It is a histological dye which binds to many amyloid proteins and is used for the quantification of amyloid β-peptide aggregation.[5] Congo red also interacts with β-D-glucans, polysaccharides containing continuous β-(1→4)-linked D-glucopyranosyl units and some hemicellulosic galactoglucomannans.[6]
signalword
Danger
hcodes
Hazard Classifications
Carc. 1B - Repr. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of ?-secretase in a mouse model of Alzheimer's disease.
He P, et al.
PLoS ONE, 8, e55091-e55091 (2013)
Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses.
Berg I, et al.
Nature Protocols, 5, 935-935 (2010)
Alejandro Llanos-Chea et al.
Journal of pediatric gastroenterology and nutrition, 68(4), 509-516 (2018-11-13)
Enteric bacterial pathogens cause diarrheal disease and mortality at significant rates throughout the world, particularly in children younger than 5 years. Our ability to combat bacterial pathogens has been hindered by antibiotic resistance, a lack of effective vaccines, and accurate
Quantifying amyloid beta-peptide (Abeta) aggregation using the Congo red-Abeta (CR-abeta) spectrophotometric assay.
Klunk WE, et al.
Analytical Biochemistry, 266, 66-66 (1999)
Kinetic study and equilibrium isotherm analysis of Congo Red adsorption by clay materials.
Vimonses V, et al.
Chemical Engineering Journal, 148, 354-364 (2009)
Related Content
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looking for Congo Red stain, the one used in histopathology, but not sure which of the options is the best.
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Why does the SDS for Congo Red list carcinogen as an OSHA hazard, (Section 2) but in Section 11 on carcinogenicity, it states that there is no component identified as a carcinogen?
1 answer-
The reason that there is not an OSHA listing for carcinogens on most of SDS that have a hazard of a carcinogen hazard is because that section of the SDS is specifically for the OSHA regulated carcinogens, also referred to as the OSHA 13. Congo red at this time is not specifically called out as a carcinogen by the other 3 Organizations listed (IARC, NTP, ACGIH) either. Congo red is listed by the European Classification Labeling & Packaging (CLP) Regulation (which is a pretty definitive guide for hazard classification), as a carcinogen. No other organizations have had the time to classify this material at this time. This is why it is only listed as a carcinogen in section 2 and in section 15.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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