P3662

Sodium pyruvate

Hybri-Max^™, powder, suitable for hybridoma

• Synonym(s): α-Ketopropionic acid sodium salt, 2-Oxopropanoic acid sodium salt, Pyruvic acid sodium salt
• Linear Formula: CH₃COCOONa
• CAS Number: 113-24-6
• Molecular Weight: 110.04
• UNSPSC Code: 12352205
• NACRES: NA.75
• PubChem Substance ID: 24898440
• EC Number: 204-024-4
• Beilstein/REAXYS Number: 3568341
• MDL number: MFCD00002586

Properties

• Product Name: Sodium pyruvate, Hybri-Max^™, powder, suitable for hybridoma
• InChI key: DAEPDZWVDSPTHF-UHFFFAOYSA-M
• InChI: 1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1
• SMILES string: [Na+].CC(=O)C([O-])=O
• biological source: synthetic (organic)
• grade: Hybri-Max^™
• assay: ≥99%
• form: powder
• technique(s): cell culture | hybridoma: suitable
• impurities: endotoxin, tested
• mp: >300 °C (lit.)
• solubility: H₂O: 100 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• Quality Level: 200

Description

Application

Sodium pyruvate is used by cells as an easily accessible carbohydrate source. Additionally, it is involved with amino acid metabolism and initiates the Kreb′s cycle. The 100 mM solution should be diluted 1:100 for most cell culture applications.

Sodium pyruvate has been used as a component in maturation medium for oocyte evaluation.[1][2][3][4]

Biochem/physiol Actions

Sodium pyruvate is known to be an effective therapeutic target for type II citrullinaemia which is characterized by hyperammonaemia.[5] In vivo studies proves that sodium pyruvate has protective function against hemorrhagic shock by preventing lipid peroxidation, NAD+ reduction and cleavage of poly(ADP-ribose) polymerases.[6] Sodium pyruvate is also known to possess anti-inflammatory action and might show improvement in chronic lung disorder.[7]

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H317,H319
• pcodes: P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Sens. 1B
• Storage Class: 13 - Non Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)