5.06382

MPTP Hydrochloride

≥98% (TLC), solid, dopaminergic neurotoxin, Calbiochem

• Synonym(s): MPTP Hydrochloride, Dopaminergic neurotoxin, MPTP
• Empirical Formula (Hill Notation): C₁₂H₁₅N · xHCl
• CAS Number: 23007-85-4
• Molecular Weight: 173.25 (free base basis)
• MDL number: MFCD00012790
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Product Name: MPTP Hydrochloride,
• Assay: ≥98% (TLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• drug control: kontrollierte Droge in Deutschland
• storage condition: OK to freeze; protect from light
• color: white
• solubility: water: 100 mg/mL
• storage temp.: 2-8°C
• SMILES string: [Cl-].[N+H]1(CCC(=CC1)c2ccccc2)C
• InChI: 1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
• InChI key: KOWJANGMTAZWDT-UHFFFAOYSA-N

Description

General description

A neurotoxin that is a precusor of MPP+ which is toxic to dopaminergic neurons and causes Parkinsonism. Widely used in research to induce Parkinson′s disease models in primates.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Langston, J. W., et al. 1985. Trends in Neurosci.8, 79.

Gabriel, T. L., et al. 1999. Nature Med.5, 1403.
Zhang, X., et al. 2010. J. Proteome Res.9, 1496.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301 - H370
• Precautionary Statements: P260 - P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - STOT SE 1
• Target Organs: Nervous system
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3