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H3393

Sigma-Aldrich

Heparin sodium salt from porcine intestinal mucosa

Grade I-A, ≥180 USP units/mg

Synonym(s):

Sodium heparin

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352201
NACRES:
NA.21

biological source

Porcine intestinal mucosa

Quality Level

type

Grade I-A

form

powder

specific activity

≥180 USP units/mg

color

beige

useful pH range

5.0 - 7.5

solubility

H2O: 50 mg/mL, clear, colorless to faintly yellow

application(s)

clinical research
diagnostic assay manufacturing
life science and biopharma

storage temp.

room temp

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General description

Heparin is a glycosaminoglycan (GAG) belonging to the mucopolysaccharides family, known for its potent anticoagulant properties. This extensively sulfated polysaccharide consists of D-glucosamine and hexuronic acid linked via glycosidic linkages. It finds wide application in biochemical research and cell culture studies.

Application

Heparin sodium salt from porcine intestinal mucosa has been supplemented in the medium prepared for insemination of oocytes with spermatozoa. Heparin sodium salt from porcine intestinal mucosa has been used:
  • to check the effect of heparin on FGF21 (fibroblast growth factor 21) signaling.
  • in immunostaining of mice brain sections
  • to quantify white blood cells and red blood cells in Sparus aurata blood samples
  • in anticoagulation and severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) inhibition assay

Biochem/physiol Actions

Heparin is mainly responsible for the delay in the coagulation of blood. It enhances the antithrombin-mediated inactivation of proteases in the coagulation pathway.

Heparin is synthesized in mast cells and mediators such as histamine and is associated with allergy and inflammatory activity. Heparin shows therapeutic effects against venous thrombosis and pulmonary embolism, helps in preventing re-thrombosis post thrombolysis, and manages arterial thrombosis in patients who suffer from acute myocardial infarction. Heparin shows anti-inflammatory action in many inflammatory conditions such as burns, bronchial asthma, and ulcerative colitis.

Other Notes

For additional information on our range of Biochemicals, please complete this form.
Heparin solutions should not be autoclaved as additional crosslinking of the sugars may occur at high temperatures. It should not be frozen as well.
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Recommended products

Heparin for diagnostic manufacturing is available as product number SRE0027

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

H3393-10KU:
H3393-1MU:
H3393-25KU:
H3393-50KU:
H3393-500KU:
H3393-100KU:
H3393-250KU:
H3393-BULK:
H3393-EW:
H3393-VAR:


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Slide 1 of 3

1 of 3

Dietary aflatoxin B1 (AFB1) reduces growth performance, impacting growth axis, metabolism, and tissue integrity in juvenile gilthead sea bream (Sparus aurata)
Barany A, et al.
Journal of Separation Science, 533 , 736189-736189 (2021)
L Peter Sarin et al.
Nucleic acids research, 37(4), 1182-1192 (2009-01-09)
The RNA-dependent RNA polymerase (RdRP) of double-stranded RNA (dsRNA) viruses performs both RNA replication and transcription. In order to initiate RNA polymerization, viral RdRPs must be able to interact with the incoming 3' terminus of the template and position it
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.
Xu J et al.
American Journal of Physiology. Endocrinology and Metabolism, 297, E1105-E1105 (2009)
Novel drug development opportunities for heparin
Lever R and Page C P
Nature Reviews Drug Discovery, 1(2) , 140-148 (2002)
The anti-inflammatory effects of heparin and related compounds
Young E, et al.
Thrombosis Research, 122(6) , 743-752 (2008)

Articles

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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