Skip to Content

Key Documents

View All Documentation

A1908

Asialofetuin from fetal calf serum

Type II (Sigma designation)

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00130561
Form:
powder
Biological source:
bovine
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

bovine

Quality Segment

type

Type II (Sigma designation)

form

powder

technique(s)

activity assay: suitable, inhibition assay: suitable

impurities

salt, essentially free, ≤1.0% N-acetylneuraminic acid

solubility

H2O: soluble 1.0 mg/mL, clear to hazy, colorless to very faintly yellow

storage temp.

2-8°C

Application

Asialofetuin from fetal calf serum is suitable for use:
  • in the assay of the lactose binding activity of the galectin-7 by immunodetection of in situ binding activity to asialofetuin immobilized on nitrocellulose
  • in the inhibition of zona pellucida hardening of mouse oocytes
  • as an acceptor in sialyltransferase enzyme activity assay
Incorporation of asialofetuin (AF) in liposomes strongly enhance delivery to and endocytosis by cells displaying the AF receptor, notably hepatocytes. This provides a very efficient route for gene therapy.

Biochem/physiol Actions

Feutins are glycoproteins that belong to the cystatin superfamily. They are characterized by the presence of two tandemly arranged cystatin-like domains and an unrelated domain. It binds to transforming growth factor (TGF)-β/BMP (bone morphogenic protein) cytokines.
Asialofetuin (AF) binds to asialoglycoprotein receptor (ASGP-R) and is employed as a ligand for drug delivery to the hepatocytes. It aids serum-resistant lipoplexes for efficient gene deliver into the HepG2 (human hepatoblastoma) cells.

Preparation Note

Enzymatic cleavage using neuraminidase

Still not finding the right product?

Explore all of our products under Asialofetuin from fetal calf serum

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

A1908-50MG: + A1908-10MG: + A1908-5MG: + A1908-VAR: + A1908-BULK:

jan

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library