Key Documents

Methotrexate hydrate

Name: Methotrexate hydrate
Brand: SIGMA
Price: 11500 JPY
Availability: InStock

powder, ≥98% (HPLC)

Synonym(s):

4-Amino-10-methylfolic acid hydrate, L-4-Amino-N¹⁰-methylpteroylglutamic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, MTX hydrate, Methylaminopterin hydrate

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Size/SKU	Availability	Price
10 mg	Available to ship TODAYfrom市川市大町368	¥11,500
25 mg	Check Cart for Availability	¥12,800
100 mg	Available to ship TODAYfrom市川市大町368	¥29,900
500 mg	Check Cart for Availability	¥134,000
1 g	Check Cart for Availability	¥235,000

About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₂N₈O₅ · xH₂O

CAS Number:

133073-73-1

Molecular Weight:

454.44 (anhydrous basis)

UNSPSC Code:

12352202

PubChem Substance ID:

57653876

NACRES:

NA.77

MDL number:

MFCD00150847

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Properties

Product Name

Methotrexate hydrate, ≥98% (HPLC), powder

biological source

synthetic (organic)

Quality Segment

200

assay

≥98% (HPLC)

form

powder

color

, yellow to very dark yellow to very dark orange

mp

185-204 °C

solubility

H₂O: insoluble

storage temp.

−20°C

SMILES string

[H]O[H].CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1

InChI key

FPJYMUQSRFJSEW-ZOWNYOTGSA-N

Gene Information

human ... DHFR(1719)

Description

Application

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems.

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.

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This Item	06563	M9929	M8407
Sigma-Aldrich A6770 Methotrexate hydrate	Sigma-Aldrich 06563 Methotrexate hydrate	Sigma-Aldrich M9929 Methotrexate	Sigma-Aldrich M8407 Methotrexate hydrate
description ≥98% (HPLC), powder	description ≥99.0% (sum of enantiomers, HPLC)	description meets USP testing specifications	description powder, BioReagent, suitable for cell culture, ≥98% (HPLC)
assay ≥98% (HPLC)	assay ≥99.0% (sum of enantiomers, HPLC)	assay 98.0-102.0%	assay ≥98% (HPLC)
biological source synthetic (organic)	biological source synthetic	biological source synthetic	biological source -
Gene Information human ... DHFR(1719)	Gene Information human ... DHFR(1719)	Gene Information human ... DHFR(1719), DHFRP1(573971), FPGS(2356), SLC19A1(6573), TYMS(7298) mouse ... Dhfr(13361) rat ... Dhfr(24312)	Gene Information human ... DHFR(1719)
Quality Level 200	Quality Level 200	Quality Level 400	Quality Level 200
form powder	form powder or crystals	form powder	form powder
solubility H₂O: insoluble	solubility water: insoluble	solubility water: insoluble	solubility H₂O: insoluble

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Pictograms

GHS06,GHS08

Signal Word

Danger

Hazard Codes

H301,H315,H319,H360FD

Precautionary Statements

P202 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

A6770-500MG: + A6770-25MG: + A6770-BULK: + A6770-1G: + A6770-10MG: + A6770-100MG: + A6770-VAR:

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Global Trade Item Number

SKU	GTIN
A6770-500MG	04061832938851
A6770-1G	04061833382813
A6770-25MG	04061833382820
A6770-10MG	04061833382806
A6770-100MG	04061833382790

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