APPA015
Caspase Activity Detection Kit
Synonym(s):
Cut-N-Glow Caspase Activity Kit
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About This Item
NACRES:
NA.32
UNSPSC Code:
12161503
Application
This kit contains sufficient reagents for one 96 well plate (96 tests)
This kit is specific for Capsase 3 (CASP-3), a member of the Caspase family (cysteine-aspartic acid protease) and when activated, is an essential factor in cell apoptosis. The Cut-N-Glow approach involves the introduction of a structural distortion into one of the complementary fragments (GFP 11), through the use of a conditionally stable tether, which serves to constrain the N and C termini of GFP 11 closely in space, thereby, diminishing the mutual affinity of the two fragments and blocking protein self-assembly until the tether is cleaved. The distortion can be reversed upon site-specific proteolysis of the tether, resulting in GFP 11 fragment assembly with GFP 1-10, generating reconstituted, functional GFP. Depending on the tether, the chimeric GFP can serve as a substrate for proteases from the three major classes: serine, cysteine, and aspartic acid.
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Storage Class
12 - Non Combustible Liquids
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
Please refer to KIT Component information
pdsc
Please refer to KIT Component information
prtr
Please refer to KIT Component information
fsl
Please refer to KIT Component information
ishl_indicated
Please refer to KIT Component information
ishl_notified
Please refer to KIT Component information
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