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CHOGS

CHOZN® ZFN-Modified CHO Cell Line

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1 vial

Estimated to ship onAugust 21, 2026from市川市大町368

¥930,000

About This Item

NACRES:
NA.75
UNSPSC Code:
12352200

¥930,000

Estimated to ship onAugust 21, 2026Details

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description

CHOZN® GS-/- ZFN-modified CHO cell line, glutamine synthetase knockout cell line

solubility

DMSO: 5 mg/mL, clear

shipped in

liquid nitrogen

storage temp.

−196°C

General description

CHOZN cell lines were created utilizing Sigma′s proprietary CompoZr Zinc Finger Nuclease (ZFN) technology to create genetic modifications in parental CHO-K1 cells. Cells are banked in chemically defined, animal component free EX-CELL CD CHO Fusion media
ZFNs are a class of engineered DNA-binding proteins and causes a double-strand break. This double-strand break is necessary for site-specific mutagenesis mediated DNA repair. It facilitates targeted genome editing by binding to a user-specified locus. Glutamine synthetase (GS) is one of the most commonly used selectable markers in the biopharmaceutical industry. Glutamine is an essential amino acid for cellular growth. The GS enzyme is responsible for the conversion of glutamate into glutamine. Without this enzymatic activity, cells can no longer synthesize glutamine endogenously and if glutamine is not supplemented in the culture media, the cells will die.

Biochem/physiol Actions

CHOZN cell lines are all subclones of the parental CHO-K1 cell line originated by Puck in 1957.

Packaging

This product is shipped in liquid nitrogen dry vapor shippers.
Liquid nitrogen dry vapor shipper fee (up to a maximum of $125) and freight not included in price of product.
Liquid nitrogen dry vapor shipper is not disposable and should be returned after receipt. A $450 liquid nitrogen dry vapor shipper fee will be charged if not returned within 1 week of delivery.
Learn more about liquid nitrogen dry vapor shipper

Physical form

CHOZN cell lines are provided to customers in vials containing >7.5e6 cells/mL

Legal Information

All CHOZN cell lines are sold under license from Sigma Aldrich. A copy of the research license is provided with purchase of the CHOZN cell lines.
CHOZN is a registered trademark of Merck KGaA, Darmstadt, Germany

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CHOZN® ZFN-Modified CHO Cell Line

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Sigma-Aldrich

SCC049

O9-1 Mouse Cranial Neural Crest Cell Line

description

-

description

Suspension-adapted in CD media

description

-

description

stably expresses stem cell markers and neural crest markers

storage temp.

−196°C

storage temp.

−196°C

storage temp.

−196°C

storage temp.

-140 to -196°C

shipped in

liquid nitrogen

shipped in

dry ice

shipped in

dry ice

shipped in

liquid nitrogen

description

CHOZN® GS-/- ZFN-modified CHO cell line, glutamine synthetase knockout cell line

description

CHOK1 cell line derived from ECACC CHO K1

description

CHOZN® DHFR-/- ZFN-modified CHO cell line, dihydrofolate reductase knockout cell line

description

-

solubility

DMSO: 5 mg/mL, clear

solubility

-

solubility

-

solubility

-

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

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