D1069

Desloratadine

≥98% (HPLC), histamine H1 receptor antagonist, powder

• Synonym(s): 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex^®, NSC 675447
• Empirical Formula (Hill Notation): C₁₉H₁₉ClN₂
• CAS Number: 100643-71-8
• Molecular Weight: 310.82
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798668
• NACRES: NA.32
• MDL number: MFCD00871949

Properties

• Product Name: Desloratadine, powder, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1
• InChI: 1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
• InChI key: JAUOIFJMECXRGI-UHFFFAOYSA-N
• Gene Information: human ... HRH1(3269)

Description

Application

Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.

Biochem/physiol Actions

A non-sedating H₁-receptor antagonist, free from antimuscarinic/anticholinergic effects. It has novel antiallergic and anti-inflammatory effects.

Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.

Legal Information

Clarinex is a registered trademark of Schering Corp.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): 390.2 °F - Pensky-Martens closed cup
• Flash Point (°C): 199 °C - Pensky-Martens closed cup