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I4034

Immepip dihydrobromide

≥97% (HPLC), H3 and H4 histamine receptor agonist, powder

Synonym(s):

4-(1H-Imidazol-4-ylmethyl)piperidine dihydrobromide

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About This Item

Empirical Formula (Hill Notation):
C9H17N3Br2
CAS Number:
164391-47-3
Molecular Weight:
327.06
UNSPSC Code:
12352200
PubChem Substance ID:
24724514
NACRES:
NA.77
MDL number:
MFCD06407876

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Product Name

Immepip dihydrobromide, ≥97% (HPLC), powder

SMILES string

Br.Br.C1CNCC(C1)Cc2c[nH]cn2

InChI key

FXFINNKFZKZVLS-UHFFFAOYSA-N

InChI

1S/C9H15N3.2BrH/c1-2-8(5-10-3-1)4-9-6-11-7-12-9;;/h6-8,10H,1-5H2,(H,11,12);2*1H

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 10 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

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This Item
I135SML1821SML1276
Immepip dihydrobromide ≥97% (HPLC), powder

Sigma-Aldrich

I4034

Immepip dihydrobromide

Imetit dihydrobromide ≥98% (HPLC)

Sigma-Aldrich

I135

Imetit dihydrobromide

Imidafenacin hydrochloride ≥95% (HPLC)

Sigma-Aldrich

SML1821

Imidafenacin hydrochloride

BAZ2-ICR ≥98% (HPLC)

Sigma-Aldrich

SML1276

BAZ2-ICR

form

powder

form

powder

form

powder

form

powder

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

H2O: 10 mg/mL, clear

solubility

H2O: 20 mg/mL, clear

solubility

H2O: 15 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

Biochem/physiol Actions

H3 and H4 histamine receptor agonist.
Immepip is a H3 and H4 histamine receptor agonist. Immepip is a selective H3 agonist equipotent to (R)-α-methylhistamine and also effective in vitro and in vivo. It is devoid of side activities elicited at H1 and α2 receptors and 5-HT3 receptors.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000184401
0000167982
0000184401
0000167982
070M4600V

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Jitendra K Singh et al.
Annals of neurosciences, 19(2), 71-75 (2012-04-01)
The histamine H3 receptor is an attractive G protein-coupled receptor drug target that regulates neurotransmission in the central nervous system and plays a crucial role in cognitive and homeostatic functions. This receptor exhibits molecular, pharmacological, and functional heterogeneity that affects
Guadalupe-Elide Morales-Figueroa et al.
Purinergic signalling, 15(1), 85-93 (2018-12-20)
We previously reported that the activation of histamine H3 receptors (H3Rs) selectively counteracts the facilitatory action of adenosine A2A receptors (A2ARs) on GABA release from rat globus pallidus (GP) isolated nerve terminals (synaptosomes). In this work, we examined the mechanisms
Balasubramaniam Annamalai et al.
ACS chemical neuroscience, 11(3), 466-476 (2020-01-10)
Reuptake and clearance of released serotonin (5-HT) are critical in serotonergic neurotransmission. Serotonin transporter (SERT) is mainly responsible for clearing the extracellular 5-HT. Controlled trafficking, phosphorylation, and protein stability have been attributed to robust SERT activity. H3 histamine receptors (H3Rs)
Nayeli Rivera-Ramírez et al.
Neurochemistry international, 101, 38-47 (2016-11-05)
The histamine H3 receptor (H3R) is abundantly expressed in the Central Nervous System where it regulates several functions pre and postsynaptically. H3Rs couple to Gαi/o proteins and trigger or modulate several intracellular signaling pathways, including the cAMP/PKA pathway and the
Gustavo Nieto-Alamilla et al.
Journal of receptor and signal transduction research, 38(2), 141-150 (2018-03-21)
In stably-transfected human neuroblastoma SH-SY5Y cells, we have compared the effect of activating two isoforms of 445 and 365 amino acids of the human histamine H3 receptor (hH3R445 and hH3R365) on [35S]-GTPγS binding, forskolin-induced cAMP formation, depolarization-induced increase in the
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