Skip to Content
Merck

S4526

Salinomycin

from Streptomyces albus, ≥98% (HPLC), powder, MDRP-1 inhibitor

Slide 1 of 3
Sign In to View Organizational & Contract Pricing

Select a Size

5 MG

¥36,050

25 MG

¥81,250

50 MG

¥98,150

¥36,050

List Price¥51,500Save 30%
Check Cart for Availability
Request a Bulk Order

About This Item

Empirical Formula (Hill Notation):
C42H70O11
CAS Number:
53003-10-4
Molecular Weight:
751.00
EC Number:
258-290-1
UNSPSC Code:
12352200
PubChem Substance ID:
329824546
NACRES:
NA.77

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Salinomycin, from Streptomyces albus, ≥98% (HPLC)

biological source

Streptomyces albus

Quality Level

200

Assay

≥98% (HPLC)

mp

112.5-113.5 °C (lit.)

antibiotic activity spectrum

neoplastics

Mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

CC[C@H]([C@H]1CC[C@H](C)[C@@H](O1)[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@H]2O[C@@]3(O[C@@]4(CC[C@](C)(O4)[C@H]5CC[C@](O)(CC)[C@H](C)O5)[C@H](O)C=C3)[C@H](C)C[C@@H]2C)C(O)=O

InChI

1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1

InChI key

KQXDHUJYNAXLNZ-XQSDOZFQSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
563080-MV363994675
Salinomycin from Streptomyces albus, ≥98% (HPLC)

Sigma-Aldrich

S4526

Salinomycin

Salinomycin Salinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug.

Millipore

563080-M

Salinomycin

Valinomycin Ready Made Solution, ~1 mg/mL in DMSO

Sigma-Aldrich

V3639

Valinomycin

Valinomycin ≥99.0% (TLC)

Sigma-Aldrich

94675

Valinomycin

assay

≥98% (HPLC)

assay

≥96% (HPLC)

assay

≥90% (HPLC)

assay

≥99.0% (TLC)

Quality Level

200

Quality Level

-

Quality Level

200

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

biological source

Streptomyces albus

biological source

-

biological source

Streptomyces sp.

biological source

-

mp

112.5-113.5 °C (lit.)

mp

-

mp

-

mp

187-190 °C

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

-

antibiotic activity spectrum

Gram-positive bacteria, parasites, viruses

antibiotic activity spectrum

mycobacteria

General description

Chemical structure: polyether

Application

Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples.[1] It was used to screen out CD44+CD24- mesenchymal-like subpopulation within breast carcinomas.[2]

Biochem/physiol Actions

Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3.[3][4] Use of salinomycin as antibiotic results in lowered spermatozoa count and motility and decreased steroidogenesis in mice.[5]

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

S4526-5MG:4548173210773
S4526-25MG:4548173210759
S4526-5MG-PW:
S4526-25MG-PW:
S4526-50MG:4548173210766
S4526-VAR:
S4526-50MG-PW:
S4526-BULK:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000462909
0000462909
0000141658
0000202393
0000419120

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Soshi Kusunoki et al.
Gynecologic oncology, 129(3), 598-605 (2013-03-19)
We previously demonstrated that side-population (SP) cells in human endometrial cancer cells (Hec1 cells) and in rat endometrial cells expressing oncogenic human K-Ras protein (RK12V cells) have features of cancer stem cells (CSCs). Hec1-SP cells showed enhanced migration and the
Jan Czerwiński et al.
Archives of animal nutrition, 66(2), 102-116 (2012-05-31)
The effect of dietary sodium butyrate (SB) or salinomycin (SAL) or both additives on performance, small intestinal morphology and microbial ecology of broiler chickens was studied. A growth trial was conducted with 96 Ross 308 female broilers from 1 to
Devraj Basu et al.
Cell cycle (Georgetown, Tex.), 10(12), 2008-2016 (2011-05-12)
Curative eradication of all cells within carcinomas is seldom achievable with chemotherapy alone. This limitation may be partially attributable to tumor cell subpopulations with intrinsic resistance to current drugs. Within squamous cell carcinoma (SCC) cell lines, we previously characterized a
J S van der Linde-Sipman et al.
Veterinary pathology, 36(2), 152-156 (1999-03-31)
In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and
Bei Zhang et al.
Oncology reports, 29(4), 1371-1378 (2013-01-23)
In order to search for alternative agents to overcome chemoresistance during the treatment of ovarian cancer, this study aimed to examine the anticancer effects and action mechanism of salinomycin, a selective inhibitor of cancer stem cells, on cisplatin-resistant human ovarian
View All Related Papers

Related Content

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service