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Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)

George Psomas, Dimitris P Kessissoglou

초록

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

MATERIALS

제품 번호

브랜드

제품 설명

Sigma-Aldrich

Nickel, wire, diam. 0.25 mm, ≥99.9%

Sigma-Aldrich

Nickel, wire, diam. 0.5 mm, ≥99.99% trace metals basis

Sigma-Aldrich

Nickel, foil, thickness 0.125 mm, ≥99.9%

Sigma-Aldrich

Nickel, powder, <1 μm, 99.8% trace metals basis

Sigma-Aldrich

Nickel, foil, thickness 0.25 mm, 99.995% trace metals basis

Sigma-Aldrich

Nickel, powder, <150 μm, 99.99% trace metals basis

Nickel, foil, 15mm disks, thickness 0.005mm, as rolled, 99.9%

Nickel, tube, 100mm, outside diameter 1.8mm, inside diameter 1.6mm, wall thickness 0.1mm, hard, 99.5%

Nickel, tube, 200mm, outside diameter 0.8mm, inside diameter 0.5mm, wall thickness 0.15mm, as drawn, 99.5%

Nickel, tube, 1000mm, outside diameter 2.5mm, inside diameter 2.25mm, wall thickness 0.125mm, hard, 99.5%

Nickel, wire reel, 200m, diameter 0.15mm, as drawn, 99%

Nickel, foil, 10mm disks, thickness 0.125mm, annealed, 99%

Nickel, foil, 10mm disks, thickness 0.125mm, as rolled, 99.99+%

Nickel, foil, 1m coil, thickness 0.50mm, annealed, 99%

Nickel, foil, 1m coil, thickness 0.05mm, as rolled, 99.98%

Nickel, foil, 10mm disks, thickness 0.25mm, annealed, 99.98%

Nickel, foil, 15mm disks, thickness 0.05mm, as rolled, 99.99+%

Nickel, tube, 100mm, outside diameter 7.11mm, inside diameter 6.57mm, wall thickness 0.27mm, hard, 99.5%

Nickel, foil, 15mm disks, thickness 0.25mm, annealed, 99%

Nickel, foil, 1m coil, thickness 0.20mm, coil width 1mm, annealed, 99%

Nickel, foil, 1m coil, thickness 0.025mm, coil width 600mm, as rolled, 99%

Nickel, foil, 10mm disks, thickness 0.125mm, annealed, 99.98%

Nickel, wire reel, 0.2m, diameter 0.4mm, as drawn, 99.99+%

Nickel, foil, 10mm disks, thickness 0.0025mm, 99.95%

Nickel, foil, 0.5m coil, thickness 0.015mm, 99.9%

Nickel, wire reel, 10m, diameter 0.5mm, hard, 99.98%

Nickel, foil, 150x150mm, thickness 0.30mm, as rolled, 99.98%

Nickel, foil, 150x150mm, thickness 0.5mm, as rolled, 99.99+%

Nickel, wire reel, 100m, diameter 0.5mm, hard, 99.98%

Nickel, foil, 4mm disks, thickness 0.015mm, 99.9%