Understanding platinum-induced ototoxicity.

Understanding platinum-induced ototoxicity.

Trends in pharmacological sciences (2013-06-19)

Thorsten Langer, Antoinette am Zehnhoff-Dinnesen, Susanne Radtke, Johannes Meitert, Oliver Zolk

초록

Childhood cancer survival rates are now nearly 80% in more developed European countries because of improved therapies and better supportive care. Platinum chemotherapy drugs, such as cisplatin and carboplatin, are the cornerstone of many effective therapeutic protocols for childhood cancer. However, the antitumor efficacy of cisplatin and carboplatin comes at the cost of ototoxicity, which affects at least 60% of pediatric patients. Although ototoxicity is not life threatening, it can have debilitating effects on patients' quality of life. Recently, many initiatives have been launched with the ultimate goal of reducing cisplatin and high-dose carboplatin ototoxicity without compromising antitumor efficacy. This review addresses the incidence of platinum ototoxicity and its clinical presentation, time course, and early diagnostic evaluation. Genetic and non-genetic risk factors for platinum-associated ototoxicity, and their predictive value, are discussed. Recent developments in the prevention of platinum ototoxicity are also summarized.

MATERIALS

제품 번호

브랜드

제품 설명

327484

Sigma-Aldrich

Platinum, shot, ≤3 mm, ≥99.9% trace metals basis

357375

Sigma-Aldrich

Platinum, wire, diam. 0.076 mm, ≥99.99% trace metals basis

267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

349380

Sigma-Aldrich

Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

298093

Sigma-Aldrich

Platinum, gauze, 100 mesh, 99.9% trace metals basis

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

520780

Sigma-Aldrich

Platinum black, ≥99.9% trace metals basis

349348

Sigma-Aldrich

Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

267821

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis

GF85632408

Platinum, foil, 6mm disks, thickness 0.025mm, as rolled, 99.99+%

GF76686924

Platinum, wire reel, 10m, diameter 0.08mm, hard, 99.9%

GF85654019

Platinum, foil, 8mm disks, thickness 0.005mm, as rolled, 99.95%

GF90209684

Platinum, wire reel, 0.5m, diameter 0.0006mm, wollaston, 99.9%

GF83172269

Platinum, foil, 0.05m coil, thickness 0.025mm, coil width .4mm, as rolled, 99.95%

GF80498391

Platinum, foil, 4mm disks, thickness 0.01mm, as rolled, 99.95%

GF95421450

Platinum, foil, not light tested, 100x100mm, thickness 0.01mm, as rolled, 99.95%

GF74454824

Platinum, wire reel, 0.1m, diameter 0.006mm, wollaston, 99.9%

GF80931955

Platinum, foil, not light tested, 25x25mm, thickness 0.005mm, as rolled, 99.95%

GF81015465

Platinum, foil, light tested, 50x50mm, thickness 0.025mm, as rolled, 99.99+%

GF89210336

Platinum, foil, 4mm disks, thickness 0.025mm, as rolled, 99.95%

GF76210994

Platinum, wire reel, 1m, diameter 0.0006mm, wollaston, 99.9%

GF84594897

Platinum, wire reel, 0.5m, diameter 0.125mm, as drawn, 99.95%

GF88232542

Platinum, foil, 15mm disks, thickness 0.025mm, as rolled, 99.95%

GF86119038

Platinum, wire reel, 0.2m, diameter 1.0mm, as drawn, 99.99+%

GF69099610

Platinum, foil, light tested, 50x50mm, thickness 0.05mm, as rolled, 99.95%

GF88759579

Platinum, wire reel, 10m, diameter 0.04mm, annealed, may be used as one component of a thermocouple, 99.99%