- New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation.
New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation.
European journal of medicinal chemistry (2017-10-17)
Fabiana Pandolfi, Daniela De Vita, Martina Bortolami, Antonio Coluccia, Roberto Di Santo, Roberta Costi, Vincenza Andrisano, Francesco Alabiso, Christian Bergamini, Romana Fato, Manuela Bartolini, Luigi Scipione
PMID29031067
초록
A new series of pyridine derivatives with carbamic or amidic function has been designed and synthesized to act as cholinesterase inhibitors. The synthesized compounds were tested toward EeAChE and hAChE and toward eqBChE and hBChE. The carbamate 8 was the most potent hAChE inhibitor (IC
MATERIALS