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Merck

C4786

Cefoxitin sodium salt

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250 MG

$197.00

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$671.00

5 G

$1,800.00

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About This Item

Empirical Formula (Hill Notation):
C16H16N3NaO7S2
CAS Number:
33564-30-6
Molecular Weight:
449.43
NACRES:
NA.24
PubChem Substance ID:
329775070
UNSPSC Code:
41116107
EC Number:
251-574-6
MDL number:
MFCD00079042

Key Documents

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InChI key

GNWUOVJNSFPWDD-XMZRARIVSA-M

InChI

1S/C16H17N3O7S2.Na/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19;/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22);/q;+1/p-1/t14-,16+;/m1./s1

SMILES string

[Na+].CO[C@]2(NC(=O)Cc1cccs1)C3SCC(COC(N)=O)=C(N3C2=O)C([O-])=O

form

powder or granules

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

storage temp.

2-8°C

Quality Level

200

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Cefoxitin sodium salt

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Cefaclor Pharmaceutical Secondary Standard; Certified Reference Material

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application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

application(s)

clinical testing

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

form

powder or granules

form

-

form

-

form

-

Quality Level

200

Quality Level

100

Quality Level

300

Quality Level

300

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Application

The analytical standard can be used to:
  • Determine cefoxitin sodium using four stability-indicating spectrophotometric methods in the presence of its alkaline degradation products in its pure form and pharmaceutical dosage forms
  • Separate and measure cefoxitin sodium in commercial drug products by high-performance liquid chromatography (HPLC)

General description

Cefoxitin is a β-lactam that belongs to the group of cephamycin antibiotics and is considered a 2nd generation cephalosporin. It shows resistance to β-lactamases and is used to treat a broad spectrum of bacterial infections caused by gram-positive and gram-negative bacteria, such as bronchitis, pharyngitis, meningitis, and urinary tract infection among others. It is used for intravenous and intramuscular injections.[1] It is found to be active against Bacteroides and is therapeutically used for the treatment of mixed aerobic-anaerobic infections.[2]

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1B

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000466566
0000466566
0000438488
0000438488
0000444789

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Methicillin-resistant Staphylococcus aureus screening by online immunometric monitoring of bacterial growth under selective pressure.
Stenholm T, et al.
Antimicrobial Agents and Chemotherapy, 53(12), 5088-5094 (2009)
Spectrofluorimetric analysis of cefoxitin in pharmaceutical dosage
Talanta, 41(4), 557-563 (1994)
Antibiotic and chemotherapy e-book, 14(3), 257-266 (2010)
Olga Snitser et al.
Nature communications, 11(1), 6038-6038 (2020-11-29)
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is threatening public health as it spreads worldwide across diverse environments. Its genetic hallmark, the mecA gene, confers resistance to many β-lactam antibiotics. Here, we show that, in addition, mecA provides a broad selective advantage
M Stegger et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(4), 395-400 (2012-03-21)
The recent finding of a new mecA homologue, mecA(LGA251) , with only 70% nucleotide homology to the conventional mecA gene has brought the routine testing for mecA as a confirmatory test for methicillin-resistant Staphylococcus aureus (MRSA) into question. A multiplex
View All Related Papers

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Product Information Sheet - C4786

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