A7910
Apolipoprotein C-II from human plasma
≥95% (SDS-PAGE)
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biological source
human
Quality Level
Assay
≥95% (SDS-PAGE)
form
powder
mol wt
average mol wt 8.8 kDa
technique(s)
ligand binding assay: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... APOC2(344)
1 of 4
This Item | RAB0612 | A7785 | SRP6300 |
|---|---|---|---|
| technique(s) ligand binding assay: suitable | technique(s) ELISA: suitable | technique(s) inhibition assay: suitable | technique(s) - |
| biological source human | biological source - | biological source human | biological source human plasma |
| assay ≥95% (SDS-PAGE) | assay - | assay ≥95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −70°C |
| form powder | form - | form lyophilized powder | form frozen liquid |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level - |
General description
Apolipoprotein C-II (APOC2/apoC-II), a small exchangeable apolipoprotein, is expressed in the liver and secreted into plasma. It is present on the triglyceride-rich lipoproteins (TRL), like chylomicrons (CM) and very-low-density lipoproteins (VLDL), and high-density lipoproteins (HDL), mainly during fasting. The intestine, macrophages, adipose tissue, brain, skin, lungs, retina, and retinal pigment epithelium are among the tissues that produce ApoC-II.[1]
Application
Apolipoprotein C-II activates lipoprotein lipase and has been used in a study to assess HDL proteome in hemodialysis patients. An excess of apolipoprotein C-II is associated with increased triglyceride-rich particles and alterations in HDL particle distribution.
Biochem/physiol Actions
Activates lipoprotein lipase
Apolipoprotein C2 (APOC2) serves as an activator of lipoprotein lipase. It is involved in the hydrolysis of triglycerides (TG) on TG-rich lipoproteins (TRL)[1] to release free fatty acids (FA).[2] Higher expression of APOC2 is observed in patient-derived glioblastoma stem cells, hypopharyngeal cancer, invasive ductal breast cancer, clear cell renal cell carcinoma, gastric cancer, centroblastic lymphoma, early-stage colorectal tumor, and skin squamous cell carcinoma.[2] ApoC-2 is considered as a new sensitive biomarker for diagnosing Takayasu arteritis (TAK).[3]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Deregulation of apolipoprotein C2 gene in cancer: A potential metabolic vulnerability.
Yuqiao Liu et al.
Clinical and translational medicine, 11(6), e406-e406 (2021-06-30)
Alain Mangé et al.
PloS one, 7(3), e34107-e34107 (2012-04-04)
Aside from a decrease in the high-density lipoprotein (HDL) cholesterol levels, qualitative abnormalities of HDL can contribute to an increase in cardiovascular (CV) risk in end-stage renal disease (ESRD) patients undergoing chronic hemodialysis (HD). Dysfunctional HDL leads to an alteration
Anna Wolska et al.
Atherosclerosis, 267, 49-60 (2017-11-04)
Apolipoprotein C-II (apoC-II) is a small exchangeable apolipoprotein found on triglyceride-rich lipoproteins (TRL), such as chylomicrons (CM) and very low-density lipoproteins (VLDL), and on high-density lipoproteins (HDL), particularly during fasting. ApoC-II plays a critical role in TRL metabolism by acting
Natsuko Tamura et al.
Scientific reports, 11(1), 18958-18958 (2021-09-25)
Takayasu arteritis (TAK) is an autoimmune systemic arteritis of unknown etiology. Although a number of investigators have attempted to determine biomarkers for diagnosing TAK, there exist no specific serological markers of this intractable disease. We undertook the exploration of novel
C E MacPhee et al.
Biochemistry, 39(12), 3433-3440 (2000-03-22)
Apolipoprotein C-II (apoC-II) is an exchangeable plasma apolipoprotein and an endogenous activator of lipoprotein lipase (LpL). Genetic deficiencies of apoC-II and overexpression of apoC-II in transgenic mice are both associated with severe hyperlipidemia, indicating a complex role for apoC-II in
Articles
Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.
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