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Merck

G110

Guanabenz acetate salt

α2 adrenoceptor agonist, powder

Synonym(s):

1-(2,6-Dichlorobenzylideneamino)guanidine acetate salt, WY-8678

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$98.50

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$222.00

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$794.00

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About This Item

Empirical Formula (Hill Notation):
C8H8Cl2N4 · C2H4O2
CAS Number:
23256-50-0
Molecular Weight:
291.13
NACRES:
NA.77
PubChem Substance ID:
24277775
UNSPSC Code:
12352200
EC Number:
245-534-7
MDL number:
MFCD00153801

Key Documents

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Product Name

Guanabenz acetate salt, powder

InChI key

MCSPBPXATWBACD-GAYQJXMFSA-N

InChI

1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;

SMILES string

CC(O)=O.NC(=N)N\N=C\c1c(Cl)cccc1Cl

form

powder

color

white

solubility

H2O: 10 mg/mL
alcohol: 50 mg/mL

originator

Wyeth

Quality Level

200

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

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1 of 4

This Item
1301404M7033H7278
Guanabenz acetate salt powder

Sigma-Aldrich

G110

Guanabenz acetate salt

Guanabenz acetate United States Pharmacopeia (USP) Reference Standard

USP

1301404

Guanabenz acetate

NG-Methyl-L-arginine acetate salt ≥98% (TLC)

Sigma-Aldrich

M7033

NG-Methyl-L-arginine acetate salt

NG-Hydroxy-L-arginine acetate salt

Sigma-Aldrich

H7278

NG-Hydroxy-L-arginine acetate salt

form

powder

form

-

form

powder

form

powder

Quality Level

200

Quality Level

-

Quality Level

200

Quality Level

200

solubility

H2O: 10 mg/mL, alcohol: 50 mg/mL

solubility

-

solubility

water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow

solubility

acetic acid: 10 mg/mL, clear, colorless to faintly yellow

color

white

color

-

color

-

color

-

originator

Wyeth

originator

-

originator

-

originator

-

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... NOS1(4842), NOS2(4843), NOS3(4846)
mouse ... Nos2(18126)
rat ... Nos1(24598), Nos2(24599)

Gene Information

-

Biochem/physiol Actions

Centrally acting α2 adrenoceptor agonist; I2 imidazoline binding site ligand; antihypertensive.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the α2-Adrenoceptors and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000474835
0000474835
0000362745
0000362746
0000327220

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Pavel Tsaytler et al.
Science (New York, N.Y.), 332(6025), 91-94 (2011-03-10)
Many biological processes are regulated through the selective dephosphorylation of proteins. Protein serine-threonine phosphatases are assembled from catalytic subunits bound to diverse regulatory subunits that provide substrate specificity and subcellular localization. We describe a small molecule, guanabenz, that bound to
Déborah Tribouillard-Tanvier et al.
PloS one, 3(4), e1981-e1981 (2008-04-24)
Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans. Here we report the discovery of the in vivo antiprion activity of Guanabenz (GA), an agonist of alpha2-adrenergic receptors routinely used in human medicine as an antihypertensive drug. We
Melissa J Fullwood et al.
Progress in molecular biology and translational science, 106, 75-106 (2012-02-22)
The unfolded protein response, also known as endoplasmic reticulum (ER) stress, has been implicated in numerous human diseases, including atherosclerosis, cancer, diabetes, and neurodegenerative disorders. Protein misfolding activates one or more of the three ER transmembrane sensors to initiate a
Pavel Tsaytler et al.
The FEBS journal, 280(2), 766-770 (2012-02-22)
Selective and reversible phosphorylation is one of the most common post-translational modifications of proteins. Although kinase inhibitors are popular in drug development programmes, selective pharmacological manipulation of phosphatase activity has been challenging to achieve. We review recent advances in the
B Holmes et al.
Drugs, 26(3), 212-229 (1983-09-01)
Guanabenz is an orally active central alpha 2-adrenoceptor agonist. Its antihypertensive action is thought to result from a decrease in sympathetic outflow from the brain to the peripheral circulatory system as a result of stimulation of central alpha 2-adrenoceptors. In
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