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Merck

S7076

SB 202190 monohydrochloride hydrate

≥98% (HPLC), solid, p38 MAP kinase inhibitor

Synonym(s):

4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole monohydrochloride hydrate, 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride hydrate

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$254.00

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About This Item

Empirical Formula (Hill Notation):
C20H14FN3O · HCl · xH2O
CAS Number:
350228-36-3
Molecular Weight:
367.80 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329824576
NACRES:
NA.77
MDL number:
MFCD17215958

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Product Name

SB 202190 monohydrochloride hydrate, ≥98% (HPLC)

SMILES string

O.Cl.Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4

InChI

1S/C20H14FN3O.ClH.H2O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15;;/h1-12,25H,(H,23,24);1H;1H2

InChI key

CZZOICWZVYZUNP-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to beige

solubility

DMSO: ≥12 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

Quality Level

100

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S7067S4317S9070
SB 202190 monohydrochloride hydrate ≥98% (HPLC)

Sigma-Aldrich

S7076

SB 202190 monohydrochloride hydrate

SB 202190 ≥98% (HPLC)

Sigma-Aldrich

S7067

SB 202190

SB 431542 hydrate ≥98% (HPLC), powder

Sigma-Aldrich

S4317

SB 431542 hydrate

SB 220025 trihydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

S9070

SB 220025 trihydrochloride

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

form

powder

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: ≥12 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: soluble 10 mg/mL, H2O: insoluble

solubility

H2O: 22 mg/mL

Application

SB 202190 may be used to inhibit p38-mediated cell signaling.
SB 202190 monohydrochloride hydrate has been used as a component of human prostate culture medium[1] and organoid culture medium[2] It has also been used as p38 mitogen activated protein kinase (MAPK) inhibitor in colon cancer cells.[3]

Biochem/physiol Actions

SB 202190 binds within the ATP pocket of p38 kinase and inhibits the p38α and β isoforms.
SB 202190 is a highly selective, potent, and cell-permeable inhibitor of p38 MAP kinase.
SB 202190 monohydrochloride hydrate mediates the phosphorylation of serine in the mutant p53 protein and modulates cell adhesion and prevents cell proliferation in breast cancer cell lines.[4]

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000372088
0000372088
0000481768
0000481766
0000429926

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Organoid culture of human prostate cancer cell lines LNCaP and C4-2B
Ma L, et al.
American journal of clinical and experimental urology, 5(3), 25-25 (2017)
Hanbing Song et al.
Nature communications, 13(1), 141-141 (2022-01-12)
Prostate cancer is the second most common malignancy in men worldwide and consists of a mixture of tumor and non-tumor cell types. To characterize the prostate cancer tumor microenvironment, we perform single-cell RNA-sequencing on prostate biopsies, prostatectomy specimens, and patient-derived
Differential effects of p38 MAP kinase inhibitors SB203580 and SB202190 on growth and migration of human MDA-MB-231 cancer cell line
Duzgun SA, et al.
Cytotechnology, 69(4), 711-724 (2017)
Organoid culture systems for prostate epithelial and cancer tissue
Drost J, et al.
Nature Protocols, 11(2), 347-347 (2016)
Rui Wang et al.
Genome medicine, 14(1), 93-93 (2022-08-17)
Colorectal cancer (CRC) ranks as the second-leading cause of cancer-related death worldwide with metastases being the main cause of cancer-related death. Here, we investigated the genomic and transcriptomic alterations in matching adjacent normal tissues, primary tumors, and metastatic tumors of
View All Related Papers

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