Skip to Content
Merck

SML0246

Tirofiban hydrochloride monohydrate

≥98% (HPLC)

Synonym(s):

L 700462, MK 383, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine

Slide 1 of 1
Sign In to View Organizational & Contract Pricing

Select a Size

10 MG

$165.00

50 MG

$661.00

$165.00

Check Cart for Availability
Request a Bulk Order

About This Item

Empirical Formula (Hill Notation):
C22H36N2O5S·HCl·H2O
CAS Number:
150915-40-5
Molecular Weight:
495.07
MDL number:
MFCD07368623
UNSPSC Code:
12352200
PubChem Substance ID:
329825256
NACRES:
NA.77

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -10 to -18° (c=1, MeOH)

storage condition

desiccated

color

white to beige

solubility

DMSO: >12 mg/mL at warmed to 60 °C

shipped in

wet ice

storage temp.

−20°C

SMILES string

OC([C@@H](NS(CCCC)(=O)=O)CC1=CC=C(C=C1)OCCCCC2CCNCC2)=O.Cl.O

InChI

1S/C22H36N2O5S.ClH.H2O/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18;;/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26);1H;1H2/t21-;;/m0../s1

InChI key

HWAAPJPFZPHHBC-FGJQBABTSA-N

Gene Information

human ... ITGA2B(3674), ITGB3(3690)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
A3480SML1010SML0066
Tirofiban hydrochloride monohydrate ≥98% (HPLC)

Sigma-Aldrich

SML0246

Tirofiban hydrochloride monohydrate

Atosiban ≥98% (HPLC)

Sigma-Aldrich

A3480

Atosiban

L-742001 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1010

L-742001 hydrochloride

NGB 2904 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0066

NGB 2904 hydrochloride

form

powder

form

lyophilized powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

solubility

DMSO: >12 mg/mL at warmed to 60 °C

solubility

H2O: ≤100 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: ≥25 mg/mL

Application

Tirofiban hydrochloride monohydrate has been used as an αIIbβ3 integrin (glycoprotein IIb/IIIa) inhibitor for mouse induced pluripotent stem cell (iPSC) culture.[1]

Biochem/physiol Actions

Tirofiban hydrochloride is a potent non-peptide, glycoprotein IIb/IIIa inhibitor. Blocks platelet aggregation and thrombus formation.
Tirofiban hydrochloride monohydrate is an αIIbβIII integrin inhibitor and an anticoagulant
Tirofiban might cause thrombocytopenia.[2]

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000498769
0000498769
0000368097
0000368097
0000470593

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Yongxuan Liu et al.
Pakistan journal of medical sciences, 36(2), 54-58 (2020-02-18)
To investigate the therapeutic effect of tirofiban hydrochloride sodium chloride injection combined with cardiovascular intervention on acute myocardial infarction. Eighty-four patients with acute myocardial infarction who were treated in our hospital from April 2017 to May 2018 were divided into
Yu-Lun Tseng et al.
Toxicology and applied pharmacology, 364, 106-113 (2018-12-29)
Collagen and convulxin induce platelet aggregation through glycoprotein VI (GPVI)-FcRγ-Syk signaling pathway. In addition, fibrinogen induces platelet activation through integrin αIIbβ3-FcγRIIa-Syk signaling pathway. We previously reported that high concentrations of selective serotonin reuptake inhibitors (SSRI) reduce platelet aggregation induced by
Xia Hong et al.
Journal of clinical laboratory analysis, 30(2), 108-113 (2014-11-27)
Activated clotting time (ACT) has been successfully applied during percutaneous coronary intervention (PCI) to monitor the extent of thrombin inhibition and anti-coagulation from unfractionated heparin (UFH) aiming to reduce the incidence of thrombotic adverse events and hemorrhagic complications. And this
C J Panebianco et al.
European cells & materials, 39, 211-226 (2020-05-13)
Back pain is a leading cause of global disability associated with intervertebral disc (IVD) pathologies. Discectomy alleviates disabling pain caused by IVD herniation without repairing annulus fibrosus (AF) defects, which can cause accelerated degeneration and recurrent pain. Biological therapies show
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (2015)
View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service