Tolfenamic acid

Name: Tolfenamic acid
Brand: SIAL
Price: 548 PLN

VETRANAL^®, analytical standard

Synonym(s):

2 (3-Chloro-2-methylanilino)benzoic acid, 2-([3-Chloro-2-methylphenyl]amino)benzoic acid

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100 MG

PLN 548.00

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₂ClNO₂

CAS Number:

13710-19-5

Molecular Weight:

261.70

NACRES:

NA.24

PubChem Substance ID:

329754793

UNSPSC Code:

41116107

EC Number:

237-264-3

MDL number:

MFCD00133865

Key Documents

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Product Name

Tolfenamic acid, VETRANAL^®, analytical standard

InChI key

YEZNLOUZAIOMLT-UHFFFAOYSA-N

InChI

1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)

SMILES string

Cc1c(Cl)cccc1Nc2ccccc2C(O)=O

grade

analytical standard

product line

VETRANAL^®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

100

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Analytical Chromatography

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Show Differences

1 of 4

This Item	T0535	92574	35364
Supelco 34073 Tolfenamic acid	Sigma-Aldrich T0535 Tolfenamic acid	Supelco 92574 Mefenamic acid	Supelco 35364 Mefenamic acid-(benzoic ring-¹³C₆)
grade analytical standard	grade -	grade analytical standard	grade analytical standard
application(s) forensics and toxicology pharmaceutical (small molecule)	application(s) -	application(s) forensics and toxicology pharmaceutical (small molecule) veterinary	application(s) forensics and toxicology pharmaceutical (small molecule)
technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) -	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable
product line VETRANAL^®	product line -	product line -	product line VETRANAL^®
shelf life limited shelf life, expiry date on the label	shelf life -	shelf life limited shelf life, expiry date on the label	shelf life limited shelf life, expiry date on the label
format neat	format -	format neat	format neat

Application

Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Non-steroidal anti-inflammatory agent. Interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

BCCG9624

BCBV5729

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Polymorph formation and nucleation mechanism of tolfenamic acid in solution: an investigation of pre-nucleation solute association.

Alessandra Mattei et al.

Pharmaceutical research, 29(2), 460-470 (2011-09-01)

Crystallization from solution involves nucleation and growth; growth conditions greatly influence self-association behaviors of solute molecules in these steps, affecting crystal packing of organic molecules. We examined the role of pre-nucleation association to provide insights into the mutual influence between

Structural features of mono- and tri-nuclear Zn(II) complexes with a non-steroidal anti-inflammatory drug as ligand.

Alketa Tarushi et al.

Dalton transactions (Cambridge, England : 2003), 41(23), 7082-7091 (2012-05-05)

The interaction of Zn(II) with the non-steroidal anti-inflammatory drug tolfenamic acid leads to the formation of the structurally characterized trinuclear [Zn(3)(tolfenamato)(6)(CH(3)OH)(2)] complex. In the presence of the N,N'-donor heterocyclic ligands 1,10-phenanthroline and 2,2'-bipyridine at a range of ratios, the mononuclear

Cobalt(II) complexes with non-steroidal anti-inflammatory drug tolfenamic acid: Structure and biological evaluation.

Sofia Tsiliou et al.

European journal of medicinal chemistry, 48, 132-142 (2011-12-31)

Cobalt(II) complexes with the non-steroidal anti-inflammatory drug tolfenamic acid in the presence or absence of nitrogen-donor heterocyclic ligands (2,2'-bipyridine, 1,10-phenanthroline, 2,2'-bipyridylamine or pyridine) have been synthesized and characterized with physicochemical and spectroscopic techniques. The deprotonated tolfenamato ligands are coordinated to

Tolfenamic acid inhibits neuroblastoma cell proliferation and induces apoptosis: a novel therapeutic agent for neuroblastoma.

Don Eslin et al.

Molecular carcinogenesis, 52(5), 377-386 (2012-01-04)

Current therapeutic options for recurrent neuroblastoma have poor outcomes that warrant the development of novel therapeutic strategies. Specificity protein (Sp) transcription factors regulate several genes involved in cell proliferation, survival, and angiogenesis. Sp1 regulates genes believed to be important determinants

Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors.

Riyaz Basha et al.

Gynecologic oncology, 122(1), 163-170 (2011-04-19)

The aberrant expression of hepatocyte growth factor and its receptor c-Met are associated with aggressive disease and poor prognosis in a variety of human malignancies including ovarian cancer (OC). Specificity protein (Sp) transcription factors have high relevance in the signaling

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