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A1887

Sigma-Aldrich

Albumin from human serum

lyophilized powder, essentially fatty acid free

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Synonym(s):
HSA
CAS Number:
EC Number:
MDL number:
eCl@ss:
42010201

biological source

human

Quality Level

Assay

≥96% (agarose gel electrophoresis)

form

lyophilized powder

mol wt

monomer calculated mol wt 66478 Da

technique(s)

ELISA: suitable
tissue culture: suitable
western blot: suitable

impurities

HIV I and HIVII, HCV and HBsAg, tested negative
≤0.007% Fatty Acids

solubility

H2O: soluble 50 mg/mL, clear to slightly hazy

UniProt accession no.

storage temp.

2-8°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI key

QYSGYZVSCZSLHT-UHFFFAOYSA-N

Gene Information

human ... ALB(213)

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This Item
A9511A8763A5843
assay

≥96% (agarose gel electrophoresis)

assay

≥97% (agarose gel electrophoresis)

assay

≥99% (agarose gel electrophoresis)

assay

≥96% (agarose gel electrophoresis)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

mol wt

monomer calculated mol wt 66478 Da

mol wt

monomer calculated mol wt 66478 Da

mol wt

monomer calculated mol wt 66478 Da

mol wt

monomer calculated mol wt 66478 Da

technique(s)

ELISA: suitable, tissue culture: suitable, western blot: suitable

technique(s)

ELISA: suitable, tissue culture: suitable, western blot: suitable

technique(s)

ELISA: suitable, tissue culture: suitable, western blot: suitable

technique(s)

-

impurities

HIV I and HIVII, HCV and HBsAg, tested negative, ≤0.007% Fatty Acids

impurities

HIV I and HIVII, HCV and HBsAg, tested negative

impurities

HIV I and HIVII, HCV and HBsAg, tested negative

impurities

HIV I and HIVII, HCV and HBsAg, tested negative, ≤1.0 EU/mg endotoxin

General description

Albumin is the most abundant plasma protein in human. It has a molecular weight of 66.5 kDa.

Application

Albumin from human serum has been used:
  • as a carrier of CPT-11 (irinotecan, Campto) and SN-38 to investigate its binding to human plasma proteins
  • to study the adsorption of water and acetonitrile (AN) vapor on a human serum albumin
  • to study its effect on wound healing process

Biochem/physiol Actions

Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influence their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has widely varied effects on its physiological function.
Serum albumin primarily mediates divalent cation transportation, fatty acid and drug complex formation and transport. The albumin levels in the serum indicate the disease progression in advanced liver disease. Low body weight and decreased serum albumin is associated with colorectal cancer.

Preparation Note

Prepared from albumin (A1653)

Other Notes

View more information on human serum albumin.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Bronchoalveolar lavage fluid from preterm infants with chorioamnionitis inhibits alveolar epithelial repair
Been JV, et al.
Respiratory Research, 10(1), 116-116 (2009)
In vitro binding and partitioning of irinotecan (CPT-11) and its metabolite, SN-38, in human blood
Combes O, et al.
Investigational New Drugs, 18(1), 1-5 (2000)
Sorption of water vapor and acetonitrile by human serum albumin
Sirotkin VA, et al.
Russian Journal of Physical Chemistry A, 76(12), 2051-2057 (2002)
Effect of acetonitrile on the hydration of human serum albumin films: a calorimetric and spectroscopic study
Sirotkin VA and Korolev DV
Thermochimica Acta, 432(2), 246-253 (2005)
Serum albumin and body weight as predictors of postoperative course in colorectal cancer
Hickman DM, et al.
Journal of Parenteral and Enteral Nutrition, 4(3), 314-316 (1980)

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