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Fas Ligand human

>95% (SDS-PAGE), recombinant, expressed in CHO cells, lyophilized powder

MDL number:


expressed in CHO cells

Quality Level


>95% (SDS-PAGE)


lyophilized powder

mol wt

monomer calculated mol wt ~18 kDa
26-28 kDa by SDS-PAGE


endotoxin, tested

UniProt accession no.

storage temp.


Gene Information

human ... FASLG(356)

General description

FASLG (Fas ligand) acts as a ligand for Fas receptor, and is a major protein involved in programmed cell death, apoptosis. Soluble Fas (sFAS) is usually detected in plasma prior to apoptosis.[1]


Fas Ligand (FASLG) human has been used for-
  • the study of FASLG stimulation in luteal cells obtained from mid-corpus luteum (CL) and
  • the study of apoptosis induction and intracellular caspase-3 assay in human cells. [2][3]

Biochem/physiol Actions

FASLG (Fas ligand) and Fas receptor constitute the basic elements in apoptosis. Interaction of FASLG with Fas receptor leads to activation of caspase-8. This caspase in turn leads to activation of effector caspases such as caspase-3, -6 and -7. This cascade results in the hydrolysis of nuclear and cytoplasmic components. Expression of FASLG is induced by nuclear factor-κB (NFκB). NFκB/FASLG pathway facilitates the suppression of p,p′-DDT (dichlorodiphenoxytrichloroethane)-induced cell toxicity by vitamin C and E.[4] In CD4+ T cells, this protein is expressed on stimulus by T-cell receptor (TCR), both during normal and pathological conditions, such as alcohol exposure.[5]
Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).

Other Notes

Human Fas Ligand, N-terminal 6X histidine-tagged, encodes amino acids 134-281.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

Analysis Note

Measured by its ability to induce apoptosis in Jurkat cells.


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Signal Word


Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

13 - Non Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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