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S8689

Sigma-Aldrich

Fas Ligand, soluble human

recombinant, expressed in HEK 293 cells, lyophilized powder

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Synonym(s):
SuperFas Ligand
MDL number:
NACRES:
NA.56

biological source

human

Quality Level

recombinant

expressed in HEK 293 cells

Assay

≥95% (SDS-GE)

form

lyophilized powder

mol wt

32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions)
35 kDa by SDS-PAGE (glycosylated form, under reducing conditions)

technique(s)

ligand binding assay: suitable

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... FASLG(356)

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technique(s)

ligand binding assay: suitable

technique(s)

-

technique(s)

-

technique(s)

-

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

biological source

human

biological source

mouse

biological source

mouse

biological source

human

mol wt

32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions), 35 kDa by SDS-PAGE (glycosylated form, under reducing conditions)

mol wt

~34 kDa by SDS-PAGE

mol wt

~22 kDa by SDS-PAGE

mol wt

~35 kDa by SDS-PAGE

form

lyophilized powder

form

lyophilized

form

liquid

form

lyophilized

Application

ED50 = 1 ng/ml on A20 cells. Does not require any enhancer, as the modified linker sequence already facilitates the formation of active FasL complexes. rhsSuperFasL recognizes its receptor Fas (CD95) of the following species: human, rat, mouse.

Biochem/physiol Actions

Fas ligand has also been shown to be involved in the activation of non-apoptotic pathways including proliferation and NF-κ B activation.
Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).

Legal Information

SuperFas Ligand is a trademark of Alexis Biochemicals Corp.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Harald Wajant et al.
Cytokine & growth factor reviews, 14(1), 53-66 (2002-12-18)
Fas (Apo-1, CD95) and Fas-Ligand (FasL, CD95L) are typical members of the TNF receptor and TNF ligand family, respectively, with a pivotal role in the regulation of apoptotic processes, including activation-induced cell death, T-cell-induced cytotoxicity, immune privilege and tumor surveillance.

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