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Merck

M1275

Naproxen sodium

synthetic (organic), 98.0-102.0%, Prostaglandin H synthase 1 and 2 inhibitor, powder

Synonym(s):

(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt

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PLN 587.00

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About This Item

Empirical Formula (Hill Notation):
C14H13NaO3
CAS Number:
26159-34-2
Molecular Weight:
252.24
NACRES:
NA.77
PubChem Substance ID:
57654352
UNSPSC Code:
12352200
EC Number:
247-486-2
MDL number:
MFCD00058507

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Product Name

Naproxen sodium, 98.0-102.0%

assay

98.0-102.0%

form

powder

InChI

1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

InChI key

CDBRNDSHEYLDJV-FVGYRXGTSA-M

SMILES string

[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O

biological source

synthetic (organic)

solubility

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

originator

Bayer

Quality Level

200

Gene Information

human ... PTGS1(5742), PTGS2(5743)

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This Item
PHR1165N51601457403
Naproxen sodium 98.0-102.0%

Sigma-Aldrich

M1275

Naproxen sodium

Naproxen sodium Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1165

Naproxen sodium

Naproxen sodium meets USP testing specifications

Sigma-Aldrich

N5160

Naproxen sodium

Naproxen sodium United States Pharmacopeia (USP) Reference Standard

USP

1457403

Naproxen sodium

form

powder

form

-

form

powder

form

-

assay

98.0-102.0%

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

300

Quality Level

100

Quality Level

-

solubility

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

-

solubility

-

solubility

-

originator

Bayer

originator

-

originator

-

originator

-

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

Application

Naproxen sodium has been used to evaluate the thermodynamics of biomolecular interaction with bovine and human serum albumin.[1] It has also been used to evaluate its efficiency in reducing the response of spinal dorsal horn neurons to noxious knee joint rotation.[2]

Biochem/physiol Actions

Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.
Naproxen binds preferably to serum albumin. The S-enantiomer of naproxen is 28-fold more potential as an anti-inflammatory drug compared to the R-isomer. The R-isomer is found to be a liver toxin and causes gastrointestinal disorders.[1]

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Naproxen belongs to phenylacetic acid class of Non-steroidal anti-inflammatory drugs (NSAIDs).[1]

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

hcodes

H302,H360

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ9146
MKCW6583
MKCV0146
MKCS5488
MKCR9926

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Jing Xia et al.
Plant communications, 4(6), 100632-100632 (2023-05-31)
The phytohormone auxin plays central roles in many growth and developmental processes in plants. Development of chemical tools targeting the auxin pathway is useful for both plant biology and agriculture. Here we reveal that naproxen, a synthetic compound with anti-inflammatory
Binding thermodynamics of Diclofenac and Naproxen with human and bovine serum albumins: A calorimetric and spectroscopic study
Bou-Abdallah F, et al.
The Journal of Chemical Thermodynamics, 103, 299-309 (2016)
Margarita Valero et al.
Langmuir : the ACS journal of surfaces and colloids, 26(13), 10561-10571 (2010-05-15)
The associative structures between F127 Pluronic micelles and four drugs, namely, lidocaine (LD), pentobarbital sodium salt (PB), sodium naproxen (NP), and sodium salicylate (SAL), were studied by small-angle neutron scattering (SANS). Different outcomes for the micellar aggregates are observed, which
Flores Martín-Reyes et al.
Antioxidants (Basel, Switzerland), 12(12) (2023-12-23)
Inflammatory Bowel Diseases (IBD) are a group of chronic, inflammatory disorders of the gut. The incidence and activity of IBD are determined by both genetic and environmental factors. Among these factors, polymorphisms in genes related to autophagy and the consumption
Arın Gül Dal et al.
Journal of analytical methods in chemistry, 2014, 352698-352698 (2014-10-09)
Simple and rapid capillary zone electrophoretic method was developed and validated in this study for the determination of piroxicam in tablets. The separation of piroxicam was conducted in a fused-silica capillary by using 10 mM borate buffer (pH 9.0) containing 10%
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