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Merck

PTGS2

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Synonyme:
COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(5743) Summary: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
  • Mouse(19225) prostaglandin-endoperoxide synthase 2
  • Rat(29527) prostaglandin-endoperoxide synthase 2
  • Goat(100860905) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • cow(282023) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • Horse(791253) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic cat(100126581) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • dog(442942) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • Domestic Rabbit(100009248) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • sheep(443460) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • naked mole-rat(101704771) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • chicken(396451) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic guinea pig(100135607) prostaglandin-endoperoxide synthase 2

Custom & Knockdown Gene Products

ELISA

Produktnummer
Beschreibung
Spezies
Human COX-2 ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Spezies
human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-Cox2 antibody produced in rabbit, ,
Speziesreaktivität
human, mouse, rat
Anwendung
immunofluorescence
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-COX-2 antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM348, purified immunoglobulin,
Speziesreaktivität
human
Anwendung
immunohistochemistry
Anti-Cyclooxygenase-2 Antibody, Chemicon®, from rabbit,
Speziesreaktivität
bovine, human, mouse, sheep
Anwendung
ELISA
western blot
Anti-COX2 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-COX2/PTGS2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Speziesreaktivität
bovine, canine, human, pig, sheep
Anwendung
ELISA
flow cytometry

immunofluorescence

western blot

Small Molecule - Blocker

Produktnummer
Beschreibung
Spezies
N-p-Tosyl-L-phenylalaninchlormethylketon, ≥97% (TLC), powder,
Spezies
human

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
Celecoxib, Pharmaceutical Secondary Standard; Certified Reference Material,
Spezies
human
Aceclofenac, ≥98% (HPLC),
Spezies
human
Carprofen, Pharmaceutical Secondary Standard; Certified Reference Material,
Spezies
human
Etoricoxib, VETRANAL®, analytical standard,
Spezies
human
Carprofen, ≥97% (HPLC),
Spezies
human

Proteins

Produktnummer
Beschreibung
Spezies
Cyclooxygenase 2 human, ≥70% (SDS-PAGE), recombinant, expressed in insect cells, aqueous solution, ≥8000 units/mg protein,
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human PTGS2,
Spezies
human
MISSION® esiRNA, targeting mouse Ptgs2,
Spezies
mouse