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Białko histonu H1, 20 mg

Purified bovine Histone H1 protein for use as a substrate in histone modification assays (HAT, HDAC, DNMT) and chromatin assembly studies.

Synonim(y):

Łącznik Histone H1

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Rozmiar/SKUDostępnośćCena netto
20 mg
Sprawdź dostępność w koszyku
2080,00 zł

Informacje o tej pozycji

UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405
Biological source:
bovine
Mol wt:
Mw 32 kDa

2080,00 zł

Sprawdź dostępność w koszyku
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biological source

bovine

Quality Segment

mol wt

Mw 32 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

UniProt accession no.

shipped in

dry ice

General description

H1 and related linker histones are important both for maintenance of higher-order chromatin structure and for the regulation of gene expression. Nucleosomal stabilization is provided through the binding of histone H1 to the nucleosomal dyad and the linker DNA entering and exiting the core particle. Additional experimental evidence illustrates the influence of histone H1 on chromatin arrangement and compaction. The family of histone H1 proteins contains five somatic variants (H1.1, H1.2, H1.3, H1.4 and H1.5) which are expressed in nearly all cell types.
Product Source: Lysine rich fraction from calf thymus

Physical form

Sterilized through a 0.2 micron membrane filter

Preparation Note

1 year at -20°C

Analysis Note

Routinely evaluated by Kinase assay using cdk2/cyclin A, active (14-448) to phosphorylate Histone H1.

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
This product is derived from bovine source. Export of this product to certain countries may be restricted. Please contact Customer Service or your local distributor to inquire about product availability and export options.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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12 - Non Combustible Liquids

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Questions

1–2 of 2 Questions  

  1. Hi can this be used for enzymatic assays?

    1 answer

    1. This product is tested in a kinase assay using cdk2/cyclin A, active (14-448), to phosphorylate histone H1. The Certificate of Analysis contains the kinase assay procedure.

      Helpful?

  2. Sowohl die NCBI- als auch die Uni-Prot Nummer führen zu einer humanen Datenkarte, anstatt zu einer bovinen. Warum?

    1 answer

    1. Thank you for notifying us about the mismatch. Please find the relevant links here:
      https://www.ncbi.nlm.nih.gov/gene/617854
      https://www.uniprot.org/uniprotkb/G3MWV5/entry

      Helpful?

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