178281

p-APMSF hydrochloride

≥97% (HPLC), irreversible trypsin-like serine proteases inhibitor, solid

• Synonim(y): p-amidynofenylometylosulfonylofluorek, HCl
• Numer CAS: 74938-88-8
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00078902
• Assay: ≥97% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated

Właściwości

• Nazwa produktu: p-APMSF, chlorowodorek, Alternative to DFP and PMSF.
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: white
• solubility: water: 25 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: F[S](=O)(=O)Cc1ccc(cc1)\C(=N\[H])\N.Cl
• InChI: 1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H
• InChI key: KHLLRHIUKOJXLL-UHFFFAOYSA-N

Opis

General description

Alternative to DFP and PMSF. An irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentration. Acts on C1r, C1s, Factor Xa, and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF.

An alternative to DFP and PMSF. Specific irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentrations. Acts on C1r, C1s, Factor Xa and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF. Stability is pH dependent: t_½ = 20 min at pH 6.0; 6 min at pH 7.0; 1 millisecond at pH 8.0.

Biochem/physiol Actions

Cell permeable: no

Primary Target
trypsin-like serine proteases

Product does not compete with ATP.

Reversible: no

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Cole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
Laura, R., et al. 1980. Biochemistry19, 4859.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable