2011

Bilirubina

solid, bile pigment, Calbiochem^®

• Synonim(y): Bilirubin
• Wzór empiryczny (zapis Hilla): C₃₃H₃₆N₄O₆
• Numer CAS: 635-65-4
• Masa cząsteczkowa: 584.66
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00005499
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Nazwa produktu: Bilirubina, Principal pigment of bile and one of the major end products of hemoglobin decomposition.
• Quality Segment: 100
• description: RTECS - DU3038000; Merck USA index - 14, 1218
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: red-brown
• solubility: chloroform: 1 mg/mL, alkaline solution: soluble
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: [nH]1c(c(c(c1\C=C4/NC(=O)C(=C/4C)C=C)C)CCC(=O)O)Cc2[nH]c(c(c2CCC(=O)O)C)\C=C3/NC(=O)C(=C/3C=C)C
• InChI: 1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
• InChI key: BPYKTIZUTYGOLE-IFADSCNNSA-N

Opis

General description

Bilirubin is an orange-yellow bile pigment[1] and one of the major end products of hemoglobin decomposition.[2] It contains conjugated double bonds and reactive hydrogen atoms. In adults, the upper limit of the normal range of bilirubin is >1mg/dL.[3] Serum levels of bilirubin in healthy newborns are less than 15 mg/dl.[4] This product corresponds to the unconjugated form.

Biochem/physiol Actions

Bilirubin is reported to cross the blood-brain barrier and exert significant antioxidant effects in the brain. This pigment aids in coloration in the various forms of jaundice.[1] Bilirubin levels act as biomarkers in liver and blood disorders.[5] Unconjugated form of bilirubin at lower levels serves as a physiological antioxidant.[2][5] However, increased concentration of bilirubin is toxic and leads to neonatal hyperbilirubinemia in neonates.[5]

Preparation Note

Unstable in basic solutions; reconstitute just prior to use.

Other Notes

Extinction coefficient (454 nm, CHCl₃):59,100-62,300 M^-1cm^-1.
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary Target

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable