208293

Inhibitor kanału chlorkowego aktywowanego wapniem, CaCCinh-A01

The Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 controls the biological activity of Calcium-activated Chloride Channel.

• Synonim(y): Kwas 6-tert-butylo-2-(furano-2-karboksyamido)-4,5,6,7-tetrahydrobenzo[b]tiofeno-3-karboksylowy, CaCC Blocker I, ANO Blocker I, Anoctamin Blocker I, TMEM16 Blocker I, TMEM16 Blocker I, ANO Blocker I, Anoctamin Blocker I, kwas 6-tert-butylo-2-(furan-2-karboksyamido)-4,5,6,7-tetrahydrobenzo[b]tiofen-3-karboksylowy, CaCC Blocker I
• Wzór empiryczny (zapis Hilla): C₁₈H₂₁NO₄S
• Numer CAS: 407587-33-1
• Masa cząsteczkowa: 347.43
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD02919058
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: DMSO: 50 mg/mL, pale yellow
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: CC(C)(C)C1CCC2=C(SC(NC(C3=CC=CO3)=O)=C2C(O)=O)C1
• InChI key: ACLUEOBQFRYTQS-UHFFFAOYSA-N

Opis

General description

An aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC₅₀ = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC₅₀ = 2.1 µM). Also available as a 100 mM solution in DMSO (Cat. No. 508628).

Packaging

Packaged under inert gas

Other Notes

Fuente, R., et al. 2011, Mol Pharmacol.73, 758.
Namkung, W., et al. 2011, J Biol Chem.286, 2365.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable